Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.contributor.author | 신동해 | * |
dc.contributor.author | 심현보 | * |
dc.contributor.author | 김완규 | * |
dc.contributor.author | 김수원 | * |
dc.contributor.author | 김지희 | * |
dc.date.accessioned | 2024-05-20T16:31:18Z | - |
dc.date.available | 2024-05-20T16:31:18Z | - |
dc.date.issued | 2024 | * |
dc.identifier.issn | 2041-1723 | * |
dc.identifier.other | OAK-34854 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/268480 | - |
dc.description.abstract | Osteoarthritis (OA) is a progressive and irreversible degenerative joint disease that is characterized by cartilage destruction, osteophyte formation, subchondral bone remodeling, and synovitis. Despite affecting millions of patients, effective and safe disease-modifying osteoarthritis drugs are lacking. Here we reveal an unexpected role for the small molecule 5-aminosalicylic acid (5-ASA), which is used as an anti-inflammatory drug in ulcerative colitis. We show that 5-ASA competes with extracellular-matrix collagen-II to bind to osteoclast-associated receptor (OSCAR) on chondrocytes. Intra-articular 5-ASA injections ameliorate OA generated by surgery-induced medial-meniscus destabilization in male mice. Significantly, this effect is also observed when 5-ASA was administered well after OA onset. Moreover, mice with DMM-induced OA that are treated with 5-ASA at weeks 8–11 and sacrificed at week 12 have thicker cartilage than untreated mice that were sacrificed at week 8. Mechanistically, 5-ASA reverses OSCAR-mediated transcriptional repression of PPARγ in articular chondrocytes, thereby suppressing COX-2-related inflammation. It also improves chondrogenesis, strongly downregulates ECM catabolism, and promotes ECM anabolism. Our results suggest that 5-ASA could serve as a DMOAD. © The Author(s) 2024. | * |
dc.language | English | * |
dc.publisher | Nature Research | * |
dc.title | 5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 15 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Nature Communications | * |
dc.identifier.doi | 10.1038/s41467-024-45174-6 | * |
dc.identifier.wosid | WOS:001156769400015 | * |
dc.identifier.scopusid | 2-s2.0-85184100287 | * |
dc.author.google | Kim | * |
dc.author.google | Jihee | * |
dc.author.google | Ryu | * |
dc.author.google | Gina | * |
dc.author.google | Seo | * |
dc.author.google | Jeongmin | * |
dc.author.google | Go | * |
dc.author.google | Miyeon | * |
dc.author.google | Gyungmin | * |
dc.author.google | Yi | * |
dc.author.google | Sol | * |
dc.author.google | Suwon | * |
dc.author.google | Lee | * |
dc.author.google | Hana | * |
dc.author.google | June-Yong | * |
dc.author.google | Han Sung | * |
dc.author.google | Park | * |
dc.author.google | Min-Chan | * |
dc.author.google | Shin | * |
dc.author.google | Dong Hae | * |
dc.author.google | Shim | * |
dc.author.google | Hyunbo | * |
dc.author.google | Wankyu | * |
dc.author.google | Soo Young | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.contributor.scopusid | 신동해(57217374185) | * |
dc.contributor.scopusid | 심현보(26635827900) | * |
dc.contributor.scopusid | 김완규(25627654100) | * |
dc.contributor.scopusid | 김수원(57193241841) | * |
dc.contributor.scopusid | 김지희(57210213807) | * |
dc.date.modifydate | 20240601081000 | * |