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Biological Reaction Engineering for the Preparation of C9 Chemicals from Oleic Acid: 9-Aminononanoic Acid, 1,9-Nonanediol, 9-Amino-1-nonanol, and 1,9-Diaminononane
- Title
- Biological Reaction Engineering for the Preparation of C9 Chemicals from Oleic Acid: 9-Aminononanoic Acid, 1,9-Nonanediol, 9-Amino-1-nonanol, and 1,9-Diaminononane
- Authors
- Hwang; Se-Yeun; Woo; Ji-Min; Choi; Go Eun; Oh; Deok-Kun; Seo; Joo-Hyun; Park; Jin-Byung
- Ewha Authors
- 박진병; 우지민
- SCOPUS Author ID
- 박진병; 우지민
- Issue Date
- 2024
- Journal Title
- ACS Catalysis
- ISSN
- 2155-5435
- Citation
- ACS Catalysis vol. 14, no. 6, pp. 4130 - 4138
- Keywords
- 1,9-diaminononane; 1,9-nonanediol; 9-amino-1-nonanol; 9-aminononanoic acid; whole-cell biocatalysis
- Publisher
- American Chemical Society
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Engineering of native and recombinant enzyme reactions in whole-cell biocatalysis may allow the production of a variety of chemicals. In particular, fine-tuning of the reaction selectivity may enable the preparation of a desired product to a high conversion. Here, we demonstrated that various C9 chemicals such as 9-aminononanoic acid, 1,9-nonanediol, 9-amino-1-nonanol, and 1,9-diaminononane could be produced from renewable C18 oleic acid. As a representative example, activation of six recombinant enzyme reactions (e.g., fatty acid double bond hydratase, long-chain secondary alcohol dehydrogenase, Baeyer-Villiger monooxygenase, lipase, primary alcohol dehydrogenase, and ω-aminotransferases) with repression of one native enzyme reaction (i.e., aldehyde dehydrogenase) in Escherichia coli-based biocatalysis led to the formation of 9-aminononanoic acid with an isolation yield of 54% from oleic acid via 10-hydroxyoctadecanoic acid, 10-keto-octadecanoic acid, 9-(nonanoyloxy)nonanoic acid, 9-hydroxynonanoic acid, and 9-oxo-nonanoic acid. This study will contribute to biosynthesis of not only ω-aminoalkanoic acids but also ω-amino-1-alkanols and α,ω-diaminoalkanes from renewable fatty acids (e.g., oleic acid and ricinoleic acid). © 2024 American Chemical Society.
- DOI
- 10.1021/acscatal.4c00302
- Appears in Collections:
- 공과대학 > 식품생명공학과 > Journal papers
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