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Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications

Title
Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications
Authors
WuXiaofengHuJing-JingYoonJuyoung
Ewha Authors
윤주영Jingjing Hu
SCOPUS Author ID
윤주영scopus
Issue Date
2024
Journal Title
Angewandte Chemie - International Edition
ISSN
1433-7851JCR Link
Citation
Angewandte Chemie - International Edition vol. 63, no. 18
Keywords
biosynthesiscell membranemembrane protein degradationphototherapyself-assembly
Publisher
John Wiley and Sons Inc
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
The cell membrane is a crucial component of cells, protecting their integrity and stability while facilitating signal transduction and information exchange. Therefore, disrupting its structure or impairing its functions can potentially cause irreversible cell damage. Presently, the tumor cell membrane is recognized as a promising therapeutic target for various treatment methods. Given the extensive research focused on cell membranes, it is both necessary and timely to discuss these developments, from materials design to specific biomedical applications. This review covers treatments based on functional materials targeting the cell membrane, ranging from well-known membrane-anchoring photodynamic therapy to recent lysosome-targeting chimaeras for protein degradation. The diverse therapeutic mechanisms are introduced in the following sections: membrane-anchoring phototherapy, self-assembly on the membrane, in situ biosynthesis on the membrane, and degradation of cell membrane proteins by chimeras. In each section, we outline the conceptual design or general structure derived from numerous studies, emphasizing representative examples to understand advancements and draw inspiration. Finally, we discuss some challenges and future directions in membrane-targeted therapy from our perspective. This review aims to engage multidisciplinary readers and encourage researchers in related fields to advance the fundamental theories and practical applications of membrane-targeting therapeutic agents. © 2024 Wiley-VCH GmbH.
DOI
10.1002/anie.202400249
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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