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Association between Thyroid Function and Insulin Resistance Indices in Korean Adolescents: Findings from the 2014–2015 Korea National Health and Nutrition Examination Survey
- Title
- Association between Thyroid Function and Insulin Resistance Indices in Korean Adolescents: Findings from the 2014–2015 Korea National Health and Nutrition Examination Survey
- Authors
- Mun; Eunji; Lee; Hye Ah; Choi; Jung Eun; Rosie; Kim; Kyung Hee; Park; Hyesook; Hae Soon
- Ewha Authors
- 김경희; 김혜순; 박혜숙; 이혜아; 이로지; 최정은
- SCOPUS Author ID
- 김경희; 김혜순; 박혜숙; 이혜아; 최정은
- Issue Date
- 2024
- Journal Title
- Children
- ISSN
- 2227-9067
- Citation
- Children vol. 11, no. 3
- Keywords
- adolescent; insulin resistance; Korea National Health and Nutrition Examination Survey (KNHANES); thyroid function
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Aim: This study investigated the sex-specific association between thyroid function and various insulin resistance (IR) indices, including noninsulin-based IR indices, in euthyroid adolescents. Methods: A total of 465 adolescents (aged 12–18 years; 255 boys and 210 girls) based on data from the 2014–2015 Korea National Health and Nutrition Examination Survey were included. Serum thyrotropin (thyroid-stimulating hormone [TSH]) and free thyroxine (fT4) were used to assess thyroid function, whereas the homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), glucose/insulin ratio (GIR), triglyceride–glucose (TyG) index, and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio were used to assess IR. The relationship between thyroid function and IR was analyzed using multiple linear regressions stratified by sex, considering obesity status. Results: The relationship between thyroid function and IR varied depending on sex and was more pronounced in the overweight/obesity subgroup for both boys and girls. In overweight and obese boys and girls, fT4 was significantly associated with HOMA-IR and QUICKI with conflicting association directions. TSH was also positively associated with the TyG index in both sexes. Conclusions: The findings suggest that the relationship between thyroid function and IR in adolescents might vary depending on sex, and the degree of association was significant in obese adolescents. © 2024 by the authors.
- DOI
- 10.3390/children11030370
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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children-11-00370.pdf(1.55 MB)
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