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Amygdala electrical stimulation for operant conditioning in rat navigation
- Title
- Amygdala electrical stimulation for operant conditioning in rat navigation
- Authors
- Lee; Youjin; Kim; Soonyoung; Cho; Yoon Kyung; Kong; Chanho; Chang; Jin Woo; Jun; Sang Beom
- Ewha Authors
- 전상범
- SCOPUS Author ID
- 전상범
- Issue Date
- 2024
- Journal Title
- Biomedical Engineering Letters
- ISSN
- 2093-9868
- Citation
- Biomedical Engineering Letters vol. 14, no. 2, pp. 291 - 306
- Keywords
- Amygdala; Electrical stimulation; Medial forebrain bundle; Neuromodulation
- Publisher
- Springer Verlag
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- There have been several attempts to navigate the locomotion of animals by neuromodulation. The most common method is animal training with electrical brain stimulation for directional cues and rewards; the basic principle is to activate dopamine-mediated neural reward pathways such as the medial forebrain bundle (MFB) when the animal correctly follows the external commands. In this study, the amygdala, which is the brain region responsible for fear modulation, was targeted for punishment training. The brain regions of MFB, amygdala, and barrel cortex were electrically stimulated for reward, punishment, and directional cues, respectively. Electrical stimulation was applied to the amygdala of rats when they failed to follow directional commands. First, two different amygdala regions, i.e., basolateral amygdala (BLA) and central amygdala (CeA), were stimulated and compared in terms of behavior responses, success and correction rates for training, and gene expression for learning and memory. Then, the training was performed in three groups: group R (MFB stimulation for reward), group P (BLA stimulation for punishment), and group RP (both MFB and BLA stimulation for reward and punishment). In group P, after the training, RNA sequencing was conducted to detect gene expression and demonstrate the effect of punishment learning. Group P showed higher success rates than group R, and group RP exhibited the most effective locomotion control among the three groups. Gene expression results imply that BLA stimulation can be more effective as a punishment in the learning process than CeA stimulation. We developed a new method to navigate rat locomotion behaviors by applying amygdala stimulation. © Korean Society of Medical and Biological Engineering 2023.
- DOI
- 10.1007/s13534-023-00336-1
- Appears in Collections:
- 공과대학 > 전자전기공학전공 > Journal papers
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