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Impact of age at diagnosis on long-term prognosis in patients with intestinal Behçet's disease
- Title
- Impact of age at diagnosis on long-term prognosis in patients with intestinal Behçet's disease
- Authors
- Chang; Ji Young; Park; Soo Jung; Jae Jun; Kim; Tae Il; Cheon; Jae Hee; Jihye
- Ewha Authors
- 차지영
- SCOPUS Author ID
- 차지영
- Issue Date
- 2024
- Journal Title
- Journal of Gastroenterology and Hepatology (Australia)
- ISSN
- 0815-9319
- Citation
- Journal of Gastroenterology and Hepatology (Australia) vol. 39, no. 3, pp. 519 - 526
- Keywords
- age of onset; Behçet's syndrome; immunosuppressive agents; intestines; surgery
- Publisher
- John Wiley and Sons Inc
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background and Aim: Although age at disease onset is considered to be a significant factor in the prognosis of Crohn's disease, little is known about its influence on the long-term prognosis of those with intestinal Behçet's disease (BD). This study aimed to evaluate the long-term clinical outcomes of patients with intestinal BD according to age of disease onset. Methods: Patients diagnosed with intestinal BD at < 18, 18–60, and > 60 years of age were classified into early-onset, adult-onset, and late-onset groups, respectively. The influence of disease onset time on clinical prognosis, including specific medical requirements, BD-related intestinal surgery, hospitalization, and emergency room visits, was compared using the log–rank test in a large cohort of patients with intestinal BD. Results: Among 780 patients, 21 (2.7%), 672 (86.2%), and 87 (11.1%) comprised the early-onset, adult-onset, and late-onset groups, respectively. Patients in the early-onset group were more likely to require immunosuppressants than those in the adult-onset group (P = 0.048). Nine (42.9%), 158 (23.5%), and 18 (20.7%) patients in the early-onset, adult-onset, and late-onset groups, respectively, underwent intestinal resection. The early-onset group exhibited a higher risk for intestinal resection than the late-onset (P = 0.043) and adult-onset (P = 0.030) groups. The late-onset group exhibited a higher risk for BD-related hospitalization than the adult-onset group (P = 0.023). Conclusions: Age at diagnosis affected the clinical course of intestinal BD, including intestinal surgery, hospitalization, and specific medical requirements. Different treatment strategies should be established according to age at diagnosis. © 2023 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
- DOI
- 10.1111/jgh.16449
- Appears in Collections:
- 간호대학 > 간호학전공 > Journal papers
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