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Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus
- Title
- Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus
- Authors
- Sakeenah; Hartson; Louise; Nguyen; Doan C.; Khosroshahi; Arezou; Lee; Saeyun; Youliang; Bugrovsky; Regina; Ishii; Yusho; F. Eun-Hyung; Sanz; Ignacio; Chen; Weirong; Hong; So-Hee; Jenks; Scott A.; Anam; Fabliha A.; Tipton; Christopher M.; Woodruff; Matthew C.; Hom; Jennifer R.; Cashman; Kevin S.; Faliti; Caterina Elisa; Wang; Xiaoqian; Kyu; Shuya; Wei; Chungwen; Scharer; Christopher D.; Mi; Tian; Hicks
- Ewha Authors
- 홍소희
- SCOPUS Author ID
- 홍소희
- Issue Date
- 2024
- Journal Title
- Nature Communications
- ISSN
- 2041-1723
- Citation
- Nature Communications vol. 15, no. 1
- Publisher
- Nature Research
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells (LLPC). Active SLE generates increased circulating antibody-secreting cells (ASC). Here, we examine the phenotypic, molecular, structural, and functional features of ASC in SLE. Relative to post-vaccination ASC in healthy controls, circulating blood ASC from patients with active SLE are enriched with newly generated mature CD19−CD138+ ASC, similar to bone marrow LLPC. ASC from patients with SLE displayed morphological features of premature maturation and a transcriptome epigenetically initiated in SLE B cells. ASC from patients with SLE exhibited elevated protein levels of CXCR4, CXCR3 and CD138, along with molecular programs that promote survival. Furthermore, they demonstrate autocrine production of APRIL and IL-10, which contributed to their prolonged in vitro survival. Our work provides insight into the mechanisms of generation, expansion, maturation and survival of SLE ASC. © The Author(s) 2024.
- DOI
- 10.1038/s41467-024-46053-w
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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