Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 홍소희 | - |
dc.date.accessioned | 2024-05-13T16:31:09Z | - |
dc.date.available | 2024-05-13T16:31:09Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.other | OAK-35202 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/268151 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells (LLPC). Active SLE generates increased circulating antibody-secreting cells (ASC). Here, we examine the phenotypic, molecular, structural, and functional features of ASC in SLE. Relative to post-vaccination ASC in healthy controls, circulating blood ASC from patients with active SLE are enriched with newly generated mature CD19−CD138+ ASC, similar to bone marrow LLPC. ASC from patients with SLE displayed morphological features of premature maturation and a transcriptome epigenetically initiated in SLE B cells. ASC from patients with SLE exhibited elevated protein levels of CXCR4, CXCR3 and CD138, along with molecular programs that promote survival. Furthermore, they demonstrate autocrine production of APRIL and IL-10, which contributed to their prolonged in vitro survival. Our work provides insight into the mechanisms of generation, expansion, maturation and survival of SLE ASC. © The Author(s) 2024. | - |
dc.language | English | - |
dc.publisher | Nature Research | - |
dc.title | Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 15 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | Nature Communications | - |
dc.identifier.doi | 10.1038/s41467-024-46053-w | - |
dc.identifier.scopusid | 2-s2.0-85186588608 | - |
dc.author.google | Sakeenah | - |
dc.author.google | Hartson | - |
dc.author.google | Louise | - |
dc.author.google | Nguyen | - |
dc.author.google | Doan C. | - |
dc.author.google | Khosroshahi | - |
dc.author.google | Arezou | - |
dc.author.google | Lee | - |
dc.author.google | Saeyun | - |
dc.author.google | Youliang | - |
dc.author.google | Bugrovsky | - |
dc.author.google | Regina | - |
dc.author.google | Ishii | - |
dc.author.google | Yusho | - |
dc.author.google | F. Eun-Hyung | - |
dc.author.google | Sanz | - |
dc.author.google | Ignacio | - |
dc.author.google | Chen | - |
dc.author.google | Weirong | - |
dc.author.google | Hong | - |
dc.author.google | So-Hee | - |
dc.author.google | Jenks | - |
dc.author.google | Scott A. | - |
dc.author.google | Anam | - |
dc.author.google | Fabliha A. | - |
dc.author.google | Tipton | - |
dc.author.google | Christopher M. | - |
dc.author.google | Woodruff | - |
dc.author.google | Matthew C. | - |
dc.author.google | Hom | - |
dc.author.google | Jennifer R. | - |
dc.author.google | Cashman | - |
dc.author.google | Kevin S. | - |
dc.author.google | Faliti | - |
dc.author.google | Caterina Elisa | - |
dc.author.google | Wang | - |
dc.author.google | Xiaoqian | - |
dc.author.google | Kyu | - |
dc.author.google | Shuya | - |
dc.author.google | Wei | - |
dc.author.google | Chungwen | - |
dc.author.google | Scharer | - |
dc.author.google | Christopher D. | - |
dc.author.google | Mi | - |
dc.author.google | Tian | - |
dc.author.google | Hicks | - |
dc.contributor.scopusid | 홍소희(57197470752) | - |
dc.date.modifydate | 20240513142157 | - |