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Safety assessment of Paeonia lactiflora root extract for a cosmetic ingredient employing the threshold of toxicological concern (TTC) approach

Title
Safety assessment of Paeonia lactiflora root extract for a cosmetic ingredient employing the threshold of toxicological concern (TTC) approach
Authors
JeonSohaLeeEun-YoungNamSang-JipLimKyung-Min
Ewha Authors
임경민남상집
SCOPUS Author ID
임경민scopus; 남상집scopus
Issue Date
2024
Journal Title
Regulatory Toxicology and Pharmacology
ISSN
0273-2300JCR Link
Citation
Regulatory Toxicology and Pharmacology vol. 149
Keywords
CosmeticsNext generation risk assessmentPaeonia lactiflora root extractThreshold of toxicological concern approach (TTC)
Publisher
Academic Press Inc.
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
Botanical extracts, widely used in cosmetics, pose a challenge to safety assessment due to their complex compositions. The threshold of toxicological concern (TTC) approach, offering a safe exposure level for cosmetic ingredients, proves to be a promising solution for ensuring the safety of cosmetic ingredients with low exposure level. We assessed the safety of Paeonia lactiflora root extract (PLR), commonly used in skin conditioning products, with the TTC. We identified 50 constituents of PLR extract from the USDA database and literature exploration. Concentration of each constituent of PLR extract was determined with the information from USDA references, literature, and experimental analysis. The genotoxicity of PLR and its constituents was assessed in vitro and in silico respectively. Cramer class of the constituents of the PLR extract was determined with Toxtree 3.1 extended decision tree using ChemTunes®. Systemic exposure of each constituent from leave-on type cosmetic products containing PLR at a 1% concentration was estimated and compared with respective TTC threshold. Two constituents exceeding TTC threshold were further analyzed for dermal absorption using in silico tools, which confirmed the safety of PLR extract in cosmetics. Collectively, we demonstrated that the TTC is a useful tool for assessing botanical extract safety in cosmetics. © 2024 Elsevier Inc.
DOI
10.1016/j.yrtph.2024.105620
Appears in Collections:
약학대학 > 약학과 > Journal papers
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