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Valorization of single-carbon chemicals by using carboligases as key enzymes
- Title
- Valorization of single-carbon chemicals by using carboligases as key enzymes
- Authors
- Cheon; Huijin; Kim; Jun-Hong; Jeong-Sun; Park; Jin-Byung
- Ewha Authors
- 박진병
- SCOPUS Author ID
- 박진병
- Issue Date
- 2024
- Journal Title
- Current Opinion in Biotechnology
- ISSN
- 0958-1669
- Citation
- Current Opinion in Biotechnology vol. 85
- Publisher
- Elsevier Ltd
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Single-carbon (C1) biorefinery plays a key role in the consumption of global greenhouse gases and a circular carbon economy. Thereby, we have focused on the valorization of C1 compounds (e.g. methanol, formaldehyde, and formate) into multicarbon products, including bioplastic monomers, glycolate, and ethylene glycol. For instance, methanol, derived from the oxidation of CH4, can be converted into glycolate, ethylene glycol, or erythrulose via formaldehyde and glycolaldehyde, employing C1 and/or C2 carboligases as essential enzymes. Escherichia coli was engineered to convert formate, produced from CO via CO2 or from CO2 directly, into glycolate. Recent progress in the design of biotransformation pathways, enzyme discovery, and engineering, as well as whole-cell biocatalyst engineering for C1 biorefinery, was addressed in this review. © 2023 Elsevier Ltd
- DOI
- 10.1016/j.copbio.2023.103047
- Appears in Collections:
- 공과대학 > 식품생명공학과 > Journal papers
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