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IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes
- Title
- IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes
- Authors
- Kim; Gyeong Min; Jihee; Lee; June-Yong; Park; Min-Chan; Soo Young
- Ewha Authors
- 이수영; 김지희
- SCOPUS Author ID
- 이수영; 김지희
- Issue Date
- 2023
- Journal Title
- Experimental and Molecular Medicine
- ISSN
- 1226-3613
- Citation
- Experimental and Molecular Medicine vol. 55, no. 12, pp. 2576 - 2585
- Publisher
- Springer Nature
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Osteoarthritis (OA) is a degenerative joint disease. While it is classically characterized by articular cartilage destruction, OA affects all tissues in the joints and is thus also accompanied by local inflammation, subchondral bone changes, and persistent pain. However, our understanding of the underlying subchondral bone dynamics during OA progression is poor. Here, we demonstrate the contribution of immunoglobulin superfamily 11 (IgSF11) to OA subchondral bone remodeling by using a murine model. In particular, IgSF11 was quickly expressed by differentiating osteoclasts and upregulated in subchondral bone soon after destabilization-of-the-medial-meniscus (DMM)-induced OA. In mice, IgSF11 deficiency not only suppressed subchondral bone changes in OA but also blocked cartilage destruction. The IgSF11-expressing cells in OA subchondral bone were found to be involved in osteoclast maturation and bone resorption and colocalized with receptor-activator of nuclear-factor κ-B (RANK), the key osteoclast differentiation factor. Thus, our study shows that blocking early subchondral bone changes in OA can ameliorate articular cartilage destruction in OA. © 2023, The Author(s).
- DOI
- 10.1038/s12276-023-01126-6
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
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