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자연과학대학
화학·나노과학전공
Journal papers
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A Class of Activatable NIR-II Photoacoustic Dyes for High-Contrast Bioimaging
Title
A Class of Activatable NIR-II Photoacoustic Dyes for High-Contrast Bioimaging
Authors
Li
;
Jiangfeng
;
Wang
;
Jiangyan
;
Xu
;
Lizhen
;
Chi
;
Hanwen
;
Liang
;
Xing
;
Yoon
;
Juyoung
;
Lin
;
Weiying
Ewha Authors
윤주영
SCOPUS Author ID
윤주영
Issue Date
2024
Journal Title
Angewandte Chemie - International Edition
ISSN
1433-7851
Citation
Angewandte Chemie - International Edition vol. 63, no. 2
Keywords
Carbon Monoxide
;
Imaging
;
NIR-II
;
Optically Tunable Group
;
Photoacoustic Dyes
Publisher
John Wiley and Sons Inc
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
Photoacoustic (PA) imaging is emerging as one of the important non-invasive imaging techniques in biomedical research. Small molecule- second near-infrared window (NIR-II) PA dyes combined with imaging data can provide comprehensive and in-depth in vivo physiological and pathological information. However, the NIR-II PA dyes usually exhibit “always-on” properties due to the lack of a readily optically tunable group, which hinders the further applications in vivo. Herein, a novel class of dyes GX have been designed and synthesized as an activatable NIR-II PA platform, in which the absorption/emission wavelength of GX-5 extends up to 1082/1360 nm. Importantly, the GX dyes have a strong tissue penetration depth and high-resolution for the mouse vasculature structures in NIR-II PA 3D imaging and high signal-to-noise ratio in NIR-II fluorescence (FL) imaging. Furthermore, to demonstrate the applicability of GX dyes, the first NIR-II PA probe GX-5-CO activated by carbon monoxide (CO) was engineered and employed to reveal the enhancement of the CO levels in the hypertensive mice by high-contrast NIR-II PA and FL imaging. We expect that many derivatives of GX dyes will be developed to afford versatile NIR-II PA platforms for designing a wide variety activatable NIR-II PA probes as biomedical tools. © 2023 Wiley-VCH GmbH.
DOI
10.1002/anie.202312632
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