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Differential Expression Patterns of Toll-like Receptors in COVID-19 Patients
- Title
- Differential Expression Patterns of Toll-like Receptors in COVID-19 Patients
- Authors
- Lee, Nawon; Ko, Ryeojin; Lee, Soo Young
- Ewha Authors
- 이수영; 고려진
- SCOPUS Author ID
- 이수영; 고려진
- Issue Date
- 2023
- Journal Title
- FRONTIERS IN BIOSCIENCE-LANDMARK
- ISSN
- 2768-6701
2768-6698
- Citation
- FRONTIERS IN BIOSCIENCE-LANDMARK vol. 28, no. 11
- Keywords
- TLR; COVID-19; SARS-CoV-2; biomarkers
- Publisher
- IMR PRESS
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Since Toll-like receptors (TLRs) recognize the earliest signs of infection or cell damage, they play fundamental roles in innate immunity. This review summarizes the numerous studies on the expression of TLRs in patients with Coronavirus disease 2019 (COVID-19). We show that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can stimulate at least six of the ten TLRs in humans and that this can shape the severity of COVID-19. Specifically, TLR2, TLR4, and TLR9 appear to play pathogenic roles while TLR3, TLR7, and TLR8 may be protective. Most have mutations that could partly explain the susceptibility phenotypes of COVID19. Further understanding the roles of TLRs in COVID-19 immunopathogenesis could reveal prognostic biomarkers and help drive the
- DOI
- 10.31083/j.fbl2811307
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
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