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Effects of the multidomain intervention with nutritional supplements on cognition and gut microbiome in early symptomatic Alzheimer's disease: a randomized controlled trial
- Title
- Effects of the multidomain intervention with nutritional supplements on cognition and gut microbiome in early symptomatic Alzheimer's disease: a randomized controlled trial
- Authors
- Jeong, Jee Hyang; Lee, Eun Hye; Kim, Geon Ha; Park, Hee Kyung; Kang, Hae Jin; Park, Yoo Kyoung; Lee, Hye Ah; Hong, Chang Hyung; Moon, So Young; Kang, Woorim; Oh, Hyun-Seok; Yoon, Hai-Jeon; Choi, Seong Hye
- Ewha Authors
- 정지향; 김건하
- SCOPUS Author ID
- 정지향; 김건하
- Issue Date
- 2023
- Journal Title
- FRONTIERS IN AGING NEUROSCIENCE
- ISSN
- 1663-4365
- Citation
- FRONTIERS IN AGING NEUROSCIENCE vol. 15
- Keywords
- Alzheimer's disease; dementia; mild cognitive impairment; prevention; multidomain intervention; nutritional supplements; gut microbiome
- Publisher
- FRONTIERS MEDIA SA
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: The SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN) is a part of the World-Wide Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (WW-FINGERS) network. This study aimed to demonstrate the effects of the SUPERBRAIN-based multidomain intervention with nutritional supplements in amyloid positive emission tomography (PET) proven early symptomatic Alzheimer's disease patients.Methods: Forty-six participants who were diagnosed with mild cognitive impairment or mild dementia and were positive in the amyloid PET study randomized into three groups: group A, the multidomain intervention with nutritional supplements; group B, nutritional supplements only; and a control group. The primary outcome was a change in the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total scale index score after an 8-week intervention. Secondary outcomes, including gut microbiome data, were also analyzed.Results: The RBANS total scale index score improved significantly in group A compared with group B (p < 0.032) and compared with the control group (p < 0.001). After intervention, beta diversity of the gut microbiome between group A and the control group increased, and patients in group A were more enriched with Bifidobacterium.Conclusion: SUPERBRAIN-based multidomain intervention with nutritional supplements improves cognition and gut microbiota in patients with early symptomatic Alzheimer's disease who were amyloid-positive by PET.
- DOI
- 10.3389/fnagi.2023.1266955
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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fnagi-15-1266955.pdf(1.39 MB)
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