Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정지향 | - |
dc.contributor.author | 김건하 | - |
dc.date.accessioned | 2024-02-15T05:11:30Z | - |
dc.date.available | 2024-02-15T05:11:30Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1663-4365 | - |
dc.identifier.other | OAK-34400 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267696 | - |
dc.description.abstract | Background: The SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN) is a part of the World-Wide Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (WW-FINGERS) network. This study aimed to demonstrate the effects of the SUPERBRAIN-based multidomain intervention with nutritional supplements in amyloid positive emission tomography (PET) proven early symptomatic Alzheimer's disease patients.Methods: Forty-six participants who were diagnosed with mild cognitive impairment or mild dementia and were positive in the amyloid PET study randomized into three groups: group A, the multidomain intervention with nutritional supplements; group B, nutritional supplements only; and a control group. The primary outcome was a change in the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total scale index score after an 8-week intervention. Secondary outcomes, including gut microbiome data, were also analyzed.Results: The RBANS total scale index score improved significantly in group A compared with group B (p < 0.032) and compared with the control group (p < 0.001). After intervention, beta diversity of the gut microbiome between group A and the control group increased, and patients in group A were more enriched with Bifidobacterium.Conclusion: SUPERBRAIN-based multidomain intervention with nutritional supplements improves cognition and gut microbiota in patients with early symptomatic Alzheimer's disease who were amyloid-positive by PET. | - |
dc.language | English | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.subject | Alzheimer's disease | - |
dc.subject | dementia | - |
dc.subject | mild cognitive impairment | - |
dc.subject | prevention | - |
dc.subject | multidomain intervention | - |
dc.subject | nutritional supplements | - |
dc.subject | gut microbiome | - |
dc.title | Effects of the multidomain intervention with nutritional supplements on cognition and gut microbiome in early symptomatic Alzheimer's disease: a randomized controlled trial | - |
dc.type | Article | - |
dc.relation.volume | 15 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | FRONTIERS IN AGING NEUROSCIENCE | - |
dc.identifier.doi | 10.3389/fnagi.2023.1266955 | - |
dc.identifier.wosid | WOS:001104848400001 | - |
dc.author.google | Jeong, Jee Hyang | - |
dc.author.google | Lee, Eun Hye | - |
dc.author.google | Kim, Geon Ha | - |
dc.author.google | Park, Hee Kyung | - |
dc.author.google | Kang, Hae Jin | - |
dc.author.google | Park, Yoo Kyoung | - |
dc.author.google | Lee, Hye Ah | - |
dc.author.google | Hong, Chang Hyung | - |
dc.author.google | Moon, So Young | - |
dc.author.google | Kang, Woorim | - |
dc.author.google | Oh, Hyun-Seok | - |
dc.author.google | Yoon, Hai-Jeon | - |
dc.author.google | Choi, Seong Hye | - |
dc.contributor.scopusid | 정지향(7402045750;57192068764) | - |
dc.contributor.scopusid | 김건하(36554502600) | - |
dc.date.modifydate | 20240208163604 | - |