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Liquid Crystal Polymer-Based Miniaturized Fully Implantable Deep Brain Stimulator
- Title
- Liquid Crystal Polymer-Based Miniaturized Fully Implantable Deep Brain Stimulator
- Authors
- Ahn; Seung-Hee; Koh; Chin Su; Park; Minkyung; Jun; Sang Beom; Chang; Jin Woo; Kim; Sung June; Jung; Hyun Ho; Jeong; Joonsoo
- Ewha Authors
- 전상범
- SCOPUS Author ID
- 전상범
- Issue Date
- 2023
- Journal Title
- Polymers
- ISSN
- 2073-4360
- Citation
- Polymers vol. 15, no. 22
- Keywords
- deep brain stimulation; implantable electronics; liquid crystal polymers; von Frey test
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A significant challenge in improving the deep brain stimulation (DBS) system is the miniaturization of the device, aiming to integrate both the stimulator and the electrode into a compact unit with a wireless charging capability to reduce invasiveness. We present a miniaturized, fully implantable, and battery-free DBS system designed for rats, using a liquid crystal polymer (LCP), a biocompatible and long-term reliable material. The system integrates the simulator circuit, the receiver coil, and a 20 mm long depth-type microelectrode array in a dome-shaped LCP package that is 13 mm in diameter and 5 mm in height. Wireless powering and control via an inductive link enable device miniaturization, allowing for full implantation and, thus, the free behavior of untethered animals. The eight-channel stimulation electrode array was microfabricated on an LCP substrate to form a multilayered system substrate, which was monolithically encapsulated by a domed LCP lid using a specialized spot-welding process. The device functionality was validated via an in vivo animal experiment using a neuropathic pain model in rats. This experiment demonstrated an increase in the mechanical withdrawal threshold of the rats with microelectrical stimulation delivered using the fully implanted device, highlighting the effectiveness of the system. © 2023 by the authors.
- DOI
- 10.3390/polym15224439
- Appears in Collections:
- 공과대학 > 전자전기공학전공 > Journal papers
- Files in This Item:
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polymers-15-04439-v2.pdf(8.44 MB)
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