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자연과학대학
화학·나노과학전공
Journal papers
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Drug-Releasing Thermogel for Osteoarthritis Induction in an Animal Model
Title
Drug-Releasing Thermogel for Osteoarthritis Induction in an Animal Model
Authors
Piao
;
Zhengyu
;
Lee
;
Hyun Jung
;
Jeong
;
Byeongmoon
Ewha Authors
정병문
SCOPUS Author ID
정병문
Issue Date
2023
Journal Title
Biomacromolecules
ISSN
1525-7797
Citation
Biomacromolecules vol. 24, no. 12, pp. 6025 - 6031
Publisher
American Chemical Society
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
The induction of disease states in animal models is an essential step in new drug discovery procedures. In this study, osteoarthritis (OA) was induced in a mouse model using a polypeptide thermogel-based sustained drug release system. Hydrophilic lactobionic acids and hydrophobic n-butyric acids were grafted onto ϵ-poly(l-lysine) to prepare a thermogelling polymer of ϵ-poly(l-lysine) grafted with lactobionic acid and butyric acid (PLLB). The gel modulus of PLLB is about 1000 Pa at 37 °C. Collagenase, which causes OA, was slowly released from the PLLB thermogel over two weeks. The PLLB formulation containing collagenases ranging from 1-10 units was intra-articularly injected into the knee of mice. OA mouse models with Osteoarthritis Research Society International (OARSI) grades of 3-6 were developed depending on the amounts of collagenase incorporated in the PLLB thermogel formulation. This study suggests that thermogel-based drug release formulations can be a precise tool for developing animal disease models in a dose-dependent manner. © 2023 American Chemical Society.
DOI
10.1021/acs.biomac.3c01111
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