Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.contributor.author | 윤이수 | * |
dc.date.accessioned | 2024-02-06T16:31:15Z | - |
dc.date.available | 2024-02-06T16:31:15Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1424-8247 | * |
dc.identifier.other | OAK-34527 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267044 | - |
dc.description.abstract | Perilla frutense var. acuta (Lamiaceae) has been used to treat indigestion, asthma, and allergies in traditional medicine. In this study, luteolin 7-O-diglucuronide (1), apigenin 7-O-diglucuronide (2), and rosmarinic acid (3) were isolated from the leaves of P. frutescens var. acuta through various chromatographic purification techniques. Several approaches were used to investigate the anti-inflammatory activity of the constituents (1–3) and their working mechanisms. In silico docking simulation demonstrated that 1–3 would work as a PPAR-α/δ/γ agonist, and in vitro PPAR-α/δ/γ transcriptional assay showed that the Perilla water extract (PWE) and 3 increased PPAR-α luciferase activity (1.71 and 1.61 times of the control (PPAR-α + PPRE, p < 0.001)). In the NF-κB luciferase assay, 1 suppressed NF-κB activity the most (56.83% at 5 µM; 74.96% at 10 µM; 79.86% at 50 µM). In addition, 1 and 2 inhibited the mRNA expression of NF-κB target genes, including Il6, Mcp1, and Tnfa, at 50 µM, and 3 suppressed the genes at the mRNA level in a dose-dependent manner. We report that 1 and 2 exert anti-inflammatory effects through NF-κB inhibition, and the PPAR-α/NF-κB signaling pathway is related to the anti-inflammatory activity of 3. © 2023 by the authors. | * |
dc.language | English | * |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | * |
dc.subject | anti-inflammation | * |
dc.subject | flavonoid diglucuronide | * |
dc.subject | nuclear factor kappa B | * |
dc.subject | Perilla frutescens var. acuta | * |
dc.subject | peroxisome proliferator-activated receptor | * |
dc.title | Anti-Inflammatory Activity of the Constituents from the Leaves of Perilla frutescens var. acuta | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Pharmaceuticals | * |
dc.identifier.doi | 10.3390/ph16121655 | * |
dc.identifier.wosid | WOS:001132186600001 | * |
dc.identifier.scopusid | 2-s2.0-85180710272 | * |
dc.author.google | Youn | * |
dc.author.google | Isoo | * |
dc.author.google | Han | * |
dc.author.google | Sujin | * |
dc.author.google | Jung | * |
dc.author.google | Hee Jin | * |
dc.author.google | Noh | * |
dc.author.google | Sang Gyun | * |
dc.author.google | Chung | * |
dc.author.google | Hae Young | * |
dc.author.google | Koo | * |
dc.author.google | Yean Kyoung | * |
dc.author.google | Shin | * |
dc.author.google | Sunhye | * |
dc.author.google | Seo | * |
dc.author.google | Eun Kyoung | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 윤이수(55699411900) | * |
dc.date.modifydate | 20240426112550 | * |