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Enhancement of the therapeutic efficacy of the MAP regimen using thiamine pyrophosphate-decorated albumin nanoclusters in osteosarcoma treatment
- Title
- Enhancement of the therapeutic efficacy of the MAP regimen using thiamine pyrophosphate-decorated albumin nanoclusters in osteosarcoma treatment
- Authors
- Yoo; So-Yeol; Mun; Yong-Hyeon; Kang; Nae-Won; Koo; Jang Mo; Lee; Dong Hwan; Ji Hoon; Sang Min; Koh; Seokjin; Park; Jong Chan; Kim; Taejung; Shin; Eun Kyung; Han Sol; Sim; Jaehoon; Keon Wook; Sang Kyum; Cho; Cheong-Weon; Myeong Gyu; Dae-Duk; Jae-Young
- Ewha Authors
- 김명규
- SCOPUS Author ID
- 김명규
- Issue Date
- 2023
- Journal Title
- Bioengineering and Translational Medicine
- ISSN
- 2380-6761
- Citation
- Bioengineering and Translational Medicine vol. 8, no. 6
- Keywords
- albumin nanoclusters; hydroxyapatites; MAP regimen; osteosarcoma; thiamine pyrophosphate
- Publisher
- John Wiley and Sons Inc
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Recent studies on osteosarcoma regimens have mainly focused on modifying the combination of antineoplastic agents rather than enhancing the therapeutic efficacy of each component. Here, an albumin nanocluster (NC)-assisted methotrexate (MTX), doxorubicin (DOX), and cisplatin (MAP) regimen with improved antitumor efficacy is presented. Human serum albumin (HSA) is decorated with thiamine pyrophosphate (TPP) to increase the affinity to the bone tumor microenvironment (TME). MTX or DOX (hydrophobic MAP components) is adsorbed to HSA-TPP via hydrophobic interactions. MTX- or DOX-adsorbed HSA-TPP NCs exhibit 20.8- and 1.64-fold higher binding affinity to hydroxyapatite, respectively, than corresponding HSA NCs, suggesting improved targeting ability to the bone TME via TPP decoration. A modified MAP regimen consisting of MTX- or DOX-adsorbed HSA-TPP NCs and free cisplatin displays a higher synergistic anticancer effect in HOS/MNNG human osteosarcoma cells than conventional MAP. TPP-decorated NCs show 1.53-fold higher tumor accumulation than unmodified NCs in an orthotopic osteosarcoma mouse model, indicating increased bone tumor distribution. As a result, the modified regimen more significantly suppresses tumor growth in vivo than solution-based conventional MAP, suggesting that HSA-TPP NC-assisted MAP may be a promising strategy for osteosarcoma treatment. © 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.
- DOI
- 10.1002/btm2.10472
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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Bioengineering Transla Med - 2022 - Yoo - Enhancement of the therapeutic efficacy of the MAP regimen using thiamine.pdf(2.97 MB)
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