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Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications

Title
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
Authors
Jeong M.Lee Y.Park J.Jung H.Lee H.
Ewha Authors
이혁진
SCOPUS Author ID
이혁진scopus
Issue Date
2023
Journal Title
Advanced Drug Delivery Reviews
ISSN
0169-409XJCR Link
Citation
Advanced Drug Delivery Reviews vol. 200
Keywords
Extrahepatic deliverylipid nanoparticles (LNPs)Repeated doseRNA therapeutics
Publisher
Elsevier B.V.
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable diseases and genetic disorders by regulating disease-related gene expression. The successful development of COVID-19 mRNA vaccines further emphasizes the potential of RNA therapeutics in the prevention of infectious diseases as well as in the treatment of chronic diseases. However, the efficient delivery of RNA into cells remains a challenge, and nanoparticle delivery systems such as lipid nanoparticles (LNPs) are necessary to fully realize the potential of RNA therapeutics. While LNPs provide a highly efficient platform for the in vivo delivery of RNA by overcoming various biological barriers, several challenges remain to be resolved for further development and regulatory approval. These include a lack of targeted delivery to extrahepatic organs and a gradual loss of therapeutic potency with repeated doses. In this review, we highlight the fundamental aspects of LNPs and their uses in the development of novel RNA therapeutics. Recent advances in LNP-based therapeutics and preclinical/clinical studies are overviewed. Lastly, we discuss the current limitations of LNPs and introduce breakthrough technologies that might overcome these challenges in future applications. © 2023 Elsevier B.V.
DOI
10.1016/j.addr.2023.114990
Appears in Collections:
약학대학 > 약학과 > Journal papers
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