Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 장준 | - |
dc.date.accessioned | 2023-11-20T16:34:41Z | - |
dc.date.available | 2023-11-20T16:34:41Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.other | OAK-33998 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/266507 | - |
dc.description.abstract | Most influenza vaccines currently in use target the highly variable hemagglutinin protein to induce neutralizing antibodies and therefore require yearly reformulation. T cell-based universal influenza vaccines focus on eliciting broadly cross-reactive T-cell responses, especially the tissue-resident memory T cell (TRM) population in the respiratory tract, providing superior protection to circulating memory T cells. This study demonstrated that intramuscular (i.m.) administration of the adenovirus-based vaccine expressing influenza virus nucleoprotein (rAd/NP) elicited weak CD8 TRM responses in the lungs and airways, and yielded poor protection against lethal influenza virus challenge. However, a novel “prime-and-deploy” strategy that combines i.m. vaccination of rAd/NP with subsequent intranasal administration of an empty adenovector induced strong NP-specific CD8+ TRM cells and provided complete protection against influenza virus challenge. Overall, our results demonstrate that this “prime-and-deploy” vaccination strategy is potentially applicable to the development of universal influenza vaccines. © 2023. The Korean Association of Immunologists. | - |
dc.language | English | - |
dc.publisher | Korean Association of Immunologists | - |
dc.subject | Adenovirus vector | - |
dc.subject | Influenza vaccine | - |
dc.subject | Intramuscular administration | - |
dc.subject | Intranasal administration | - |
dc.subject | Lung CD8 T<sub>RM</sub> | - |
dc.title | Vaccine Strategy That Enhances the Protective Efficacy of Systemic Immunization by Establishing Lung-Resident Memory CD8 T Cells Against Influenza Infection | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 23 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.journaltitle | Immune Network | - |
dc.identifier.doi | 10.4110/in.2023.23.e32 | - |
dc.identifier.wosid | WOS:001061355700007 | - |
dc.identifier.scopusid | 2-s2.0-85171638927 | - |
dc.author.google | Kong H.-J. | - |
dc.author.google | Chang J. | - |
dc.author.google | Choi Y. | - |
dc.author.google | Kim E.-A. | - |
dc.contributor.scopusid | 장준(8735999100) | - |
dc.date.modifydate | 20231120165756 | - |