Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원석 | * |
dc.contributor.author | 권용주 | * |
dc.date.accessioned | 2023-10-23T16:30:47Z | - |
dc.date.available | 2023-10-23T16:30:47Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 2532-2964 | * |
dc.identifier.other | OAK-34077 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/266446 | - |
dc.description.abstract | The ortho-selective alkynylation of polyhalo-substituted (hetero)aryl tosylates was investigated using an integrated continuous-flow/batch protocol. Without the elimination of the tosyloxy group, the regioselective ortho-metalation of the (hetero)aryl tosylates employing n-BuLi and ZnCl2 was successfully achieved in continuous-flow chemistry within 10.92 s (residence time). The Pd-catalyzed Negishi alkynylations of various iodoethynyl (hetero)arenes and the resulting arylzinc species proceeded at room temperature in yields ranging from 51% to 95%. Finally, the synthetic utility of this strategy was validated by the synthesis of benzofuran and pyridofuran derivatives. © 2023 Korean Chemical Society, Seoul & Wiley-VCH GmbH. | * |
dc.language | English | * |
dc.publisher | John Wiley and Sons Inc | * |
dc.subject | alkynylation | * |
dc.subject | flow chemistry | * |
dc.subject | Negishi coupling | * |
dc.subject | regioselectivity | * |
dc.subject | zincation | * |
dc.title | Integrated continuous-flow/batch protocol for ortho-selective alkynylation of (hetero)aryl tosylates | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 44 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 772 | * |
dc.relation.lastpage | 776 | * |
dc.relation.journaltitle | Bulletin of the Korean Chemical Society | * |
dc.identifier.doi | 10.1002/bkcs.12717 | * |
dc.identifier.scopusid | 2-s2.0-85159342701 | * |
dc.author.google | Ju E.-H. | * |
dc.author.google | Lee M.-J. | * |
dc.author.google | Song J. | * |
dc.author.google | Kwon Y.-J. | * |
dc.author.google | Kim W.-S. | * |
dc.contributor.scopusid | 김원석(57203484044) | * |
dc.contributor.scopusid | 권용주(57192714799) | * |
dc.date.modifydate | 20240318130702 | * |