Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영미 | * |
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2023-10-23T16:30:46Z | - |
dc.date.available | 2023-10-23T16:30:46Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1523-7060 | * |
dc.identifier.issn | 1523-7052 | * |
dc.identifier.other | OAK-34000 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/266440 | - |
dc.description.abstract | Daldipyrenones A-C (1-3), three unprecedented caged xanthone [6,6,6,6,6] polyketides featuring a spiro-azaphilone unit, were discovered from an endolichenic fungus, Daldinia pyrenaica 047188. The structures of 1-3 were determined by using spectroscopic analysis and chemical derivatization. Daldipyrenones are likely derived by combining a chromane biosynthesis intermediate, 1-(2,6-dihydroxyphenyl)but-2-en-2-one, and a spiro-azaphilone, pestafolide A, via radical coupling or Michael addition to form a bicyclo[2.2.2]octane ring. Genome sequencing of the strain revealed two separate biosynthetic gene clusters responsible for forming two biosynthetic intermediates, suggesting a proposed biosynthetic pathway. Daldipyrenone A (1) exhibited significant antimelanogenic activity with lower EC50's than positive controls and moderate adiponectin-secretion promoting activity. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | Daldipyrenones A-C: Caged [6,6,6,6,6] Polyketides Derived from an Endolichenic Fungus <i>Daldinia pyrenaica</i> 047188 | * |
dc.type | Article | * |
dc.relation.issue | 36 | * |
dc.relation.volume | 25 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 6725 | * |
dc.relation.lastpage | 6729 | * |
dc.relation.journaltitle | ORGANIC LETTERS | * |
dc.identifier.doi | 10.1021/acs.orglett.3c02583 | * |
dc.identifier.wosid | WOS:001061525400001 | * |
dc.author.google | Lee, Seungjin | * |
dc.author.google | Park, In Guk | * |
dc.author.google | Choi, Jin Won | * |
dc.author.google | Son, Jin Young | * |
dc.author.google | Lee, Jin Woo | * |
dc.author.google | Hur, Jae-Seoun | * |
dc.author.google | Kim, Youngmee | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Kang, Hahk-Soo | * |
dc.author.google | Deyrup, Stephen T. | * |
dc.author.google | Noh, Minsoo | * |
dc.author.google | Shim, Sang Hee | * |
dc.contributor.scopusid | 김영미(57207443602) | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240301081003 | * |