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Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance
- Title
- Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance
- Authors
- Noh K.; Cho W.-H.; Lee B.H.; Kim D.W.; Kim Y.S.; Park K.; Hwang M.; Barcelon E.; Cho Y.K.; Lee C.J.; Yoon B.-E.; Choi S.-Y.; Park H.Y.; Jun S.B.; Lee S.J.
- Ewha Authors
- 전상범
- SCOPUS Author ID
- 전상범
- Issue Date
- 2023
- Journal Title
- Nature Neuroscience
- ISSN
- 1097-6256
- Citation
- Nature Neuroscience vol. 26, no. 9, pp. 1541 - 1554
- Publisher
- Nature Research
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Social hierarchy is established as an outcome of individual social behaviors, such as dominance behavior during long-term interactions with others. Astrocytes are implicated in optimizing the balance between excitatory and inhibitory (E/I) neuronal activity, which may influence social behavior. However, the contribution of astrocytes in the prefrontal cortex to dominance behavior is unclear. Here we show that dorsomedial prefrontal cortical (dmPFC) astrocytes modulate E/I balance and dominance behavior in adult male mice using in vivo fiber photometry and two-photon microscopy. Optogenetic and chemogenetic activation or inhibition of dmPFC astrocytes show that astrocytes bidirectionally control male mouse dominance behavior, affecting social rank. Dominant and subordinate male mice present distinct prefrontal synaptic E/I balance, regulated by astrocyte activity. Mechanistically, we show that dmPFC astrocytes control cortical E/I balance by simultaneously enhancing presynaptic-excitatory and reducing postsynaptic-inhibitory transmission via astrocyte-derived glutamate and ATP release, respectively. Our findings show how dmPFC astrocyte–neuron communication can be involved in the establishment of social hierarchy in adult male mice. © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
- DOI
- 10.1038/s41593-023-01406-4
- Appears in Collections:
- 공과대학 > 전자전기공학전공 > Journal papers
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