Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서원효 | * |
dc.date.accessioned | 2023-10-19T16:31:17Z | - |
dc.date.available | 2023-10-19T16:31:17Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 2047-4830 | * |
dc.identifier.other | OAK-34125 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/266290 | - |
dc.description.abstract | Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease of the digestive tract that causes pain and weight loss and also increases the risk of colon cancer. Inspired by the benefits of plant-derived nanovesicles and aloe, we herein report aloe-derived nanovesicles, including aloe vera-derived nanovesicles (VNVs), aloe arborescens-derived nanovesicles (ANVs), and aloe saponaria-derived nanovesicles (SNVs) and evaluate their therapeutic potential and molecular mechanisms in a dextran sulfate sodium (DSS)-induced acute experimental colitis mouse model. Aloe-derived nanovesicles not only facilitate markedly reduced DSS-induced acute colonic inflammation, but also enable the restoration of tight junction (TJ) and adherent junction (AJ) proteins to prevent gut permeability in DSS-induced acute colonic injury. These therapeutic effects are ascribed to the anti-inflammatory and anti-oxidant effects of aloe-derived nanovesicles. Therefore, aloe-derived nanovesicles are a safe treatment option for IBD. © 2023 The Royal Society of Chemistry. | * |
dc.language | English | * |
dc.publisher | Royal Society of Chemistry | * |
dc.title | Aloe-derived nanovesicles attenuate inflammation and enhance tight junction proteins for acute colitis treatment | * |
dc.type | Article | * |
dc.relation.issue | 16 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 5490 | * |
dc.relation.lastpage | 5501 | * |
dc.relation.journaltitle | Biomaterials Science | * |
dc.identifier.doi | 10.1039/d3bm00591g | * |
dc.identifier.scopusid | 2-s2.0-85167472206 | * |
dc.author.google | Choi S.-H. | * |
dc.author.google | Eom J.-Y. | * |
dc.author.google | Kim H.-J. | * |
dc.author.google | Seo W. | * |
dc.author.google | Kwun H.-J. | * |
dc.author.google | Kim D.-K. | * |
dc.author.google | Kim J. | * |
dc.author.google | Cho Y.-E. | * |
dc.contributor.scopusid | 서원효(56335935100) | * |
dc.date.modifydate | 20240315114146 | * |