Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김휘영 | * |
dc.contributor.author | 이혜아 | * |
dc.date.accessioned | 2023-08-03T16:31:09Z | - |
dc.date.available | 2023-08-03T16:31:09Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 2218-1989 | * |
dc.identifier.other | OAK-33369 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/265511 | - |
dc.description.abstract | Noninvasive risk stratification is a challenging issue in the management of patients with nonalcoholic fatty liver disease (NAFLD). This study aimed to identify multiomics-based predictors of NAFLD progression, as assessed by changes in serial FibroScan-aspartate aminotransferase (FAST) scores during lifestyle modification. A total of 266 patients with available metabolomics and genotyping data were included. The follow-up sub-cohort included patients with paired laboratory and transient elastography results (n = 160). The baseline median FAST score was 0.37. The PNPLA3 rs738409 genotype was significantly associated with a FAST score > 0.35. Circulating metabolomics significantly associated with a FAST score > 0.35 included SM C24:0 (odds ratio [OR] = 0.642; 95% confidence interval [CI], 0.463–0.891), PC ae C40:6 (OR = 0.477; 95% CI, 0.340–0.669), lysoPC a C18:2 (OR = 0.570; 95% CI, 0.417–0.779), and tyrosine (OR = 2.743; 95% CI, 1.875–4.014). A combination of these metabolites and PNPLA3 genotype yielded a c-index = 0.948 for predicting a FAST score > 0.35. In the follow-up sub-cohort (median follow-up = 23.7 months), 47/76 patients (61.8%) with a baseline FAST score > 0.35 had a follow-up FAST score ≤ 0.35. An improved FAST score at follow-up was significantly associated with age, serum alanine aminotransferase, and tyrosine. In conclusion, baseline risk stratification in NAFLD patients may be assisted using a multiomics-based model. Particularly, patients with increased tyrosine may benefit from an earlier switch to pharmacologic approaches. © 2023 by the authors. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | genomics | * |
dc.subject | metabolomics | * |
dc.subject | multiomics | * |
dc.subject | nonalcoholic steatohepatitis | * |
dc.subject | outcome | * |
dc.subject | prediction | * |
dc.subject | risk stratification | * |
dc.subject | steatohepatitis | * |
dc.subject | steatosis | * |
dc.subject | weight change | * |
dc.title | Baseline Tyrosine Level Is Associated with Dynamic Changes in FAST Score in NAFLD Patients under Lifestyle Modification | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Metabolites | * |
dc.identifier.doi | 10.3390/metabo13030444 | * |
dc.identifier.wosid | WOS:000959930700001 | * |
dc.identifier.scopusid | 2-s2.0-85152087023 | * |
dc.author.google | Kim H.Y. | * |
dc.author.google | Kim D.J. | * |
dc.author.google | Lee H.A. | * |
dc.author.google | Cho J.-Y. | * |
dc.author.google | Kim W. | * |
dc.contributor.scopusid | 김휘영(56493773500) | * |
dc.contributor.scopusid | 이혜아(57188947704) | * |
dc.date.modifydate | 20240429140130 | * |