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Intact Recognition Memory and Altered Hippocampal Glucocorticoid Receptor Signaling in Fkbp5-deficient Mice Following Acute Uncontrollable Stress
- Title
- Intact Recognition Memory and Altered Hippocampal Glucocorticoid Receptor Signaling in Fkbp5-deficient Mice Following Acute Uncontrollable Stress
- Authors
- Jeon Y.-J.; Choi B.-R.; Park M.-S.; Jang Y.-S.; Yoon S.; Lyoo I.K.; Han J.-S.
- Ewha Authors
- 류인균; 윤수정
- SCOPUS Author ID
- 류인균; 윤수정
- Issue Date
- 2023
- Journal Title
- Experimental Neurobiology
- ISSN
- 1226-2560
- Citation
- Experimental Neurobiology vol. 32, no. 2, pp. 91 - 101
- Keywords
- FKBP5; Glucocorticoid receptor; Hippocampus; Memory; Mice
- Publisher
- Korean Society for Neurodegenerative Disease
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- The FK506 binding protein 5 (FKBP5) is a co-chaperone that regulates the activity of the glucocorticoid receptor (GR) and has been reported to mediate stress resilience. This study aimed to determine the effects of Fkbp5 deletion on acute stress-induced recognition memory impairment and hippocampal GR signaling. Wild-type and Fkbp5 -knockout mice were subjected to acute uncontrollable stress induced by restraint and electrical tail shock. First, we assessed the cognitive status of mice using a novel object recognition task. Next, we measured plasma corticosterone, GR levels, and the levels of GR phosphorylation at serine 211 in the hippocampus. Wild-type mice exhibited stress-induced memory impairments, whereas Fkbp5 -knockout mice did not. Plasma corticosterone and GR levels did not differ between the non-stressed wild-type and Fkbp5 -knockout mice, but the levels of phosphorylated GR were lower in Fkbp5 -knockout mice than in wild-type mice. Wild-type and Fkbp5 -knockout mice showed increased nuclear GR levels following stress, indicating GR translocation. However, cytosolic phosphorylated GR levels were lower in the hippocampi of Fkbp5 -knockout mice following stress than in those of wild-type mice. These results suggest that FKBP5 deficiency increases resilience to acute stress by altering GR signaling. Copyright © Experimental Neurobiology 2023.
- DOI
- 10.5607/en23006
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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