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Di-indenopyridines as topoisomerase II-selective anticancer agents: Design, synthesis, and structure–activity relationships
- Title
- Di-indenopyridines as topoisomerase II-selective anticancer agents: Design, synthesis, and structure–activity relationships
- Authors
- Shrestha A.; Hwang S.-Y.; Kunwar S.; Man Kadayat T.; Park S.; Liu Y.; Jo H.; Sheen N.; Seo M.; Lee E.-S.; Kwon Y.
- Ewha Authors
- 권영주; 황수연; 박서정
- SCOPUS Author ID
- 권영주; 황수연; 박서정
- Issue Date
- 2023
- Journal Title
- Bioorganic and Medicinal Chemistry
- ISSN
- 9680-0896
- Citation
- Bioorganic and Medicinal Chemistry vol. 91
- Keywords
- Antiproliferative activity; Di-indenopyridines; Structure-activity relationships; Topoisomerase; Topoisomerase inhibition
- Publisher
- Elsevier Ltd
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Topoisomerases are key molecular enzymes responsible for altering DNA topology, thus they have long been considered as attractive targets for novel chemotherapeutic agents. Topoisomerase type II (Topo II) catalytic inhibitors embrace a fresh perspective meant to get beyond drawbacks caused by topo II poisons, such as cardiotoxicity and secondary malignancies. Based on previously reported 5H-indeno[1,2-b]pyridines, here we presented new twenty-three hybrid di-indenopyridines along with their topo I/IIα inhibitory and antiproliferative activity. Most of the prepared 11-phenyl-diindenopyridines showed negligible topo I inhibitory activity, showing selectivity over topo II. Among the series, we finally selected compound 17, which displayed 100 % topo IIα inhibition at 20 μM concentration and comparable antiproliferative activity against the tested cell lines. Through competitive EtBr displacement assay, cleavable complex assay, and comet assay, compound 17 was finally determined as a non-intercalative catalytic topo IIα inhibitor. The findings in this study highlight the significance of phenolic, halophenyl, thienyl, and furyl groups at the 4-position of the indane ring in the design and synthesis of di-indenopyridines as potent catalytic topo IIα inhibitors with remarkable anticancer effects. © 2023 Elsevier Ltd
- DOI
- 10.1016/j.bmc.2023.117403
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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