Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상기 | * |
dc.contributor.author | 김원석 | * |
dc.contributor.author | 권용주 | * |
dc.date.accessioned | 2023-03-03T16:30:07Z | - |
dc.date.available | 2023-03-03T16:30:07Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 0022-3263 | * |
dc.identifier.issn | 1520-6904 | * |
dc.identifier.other | OAK-32981 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/264665 | - |
dc.description.abstract | The continuous flow synthesis of N-sulfonyl-1,2,3triazoles, which are convenient reactive azavinyl carbene precursors, for tandem relay Cu/Rh dual catalysis has been developed. Most reactions readily proceeded at 75 degrees C in a short residence time of 13.09 min in the presence of 2.5 mol % of CuTC. The scope of the reactions was explored by synthesizing diversely functionalized N-sulfonyl and sulfamoyl triazoles in yields ranging from 92 to 98%. To demonstrate the scalability of the process, the reaction was conducted on a 5.4 mmol scale with residence and collection times of 13.09 and 60 min, respectively. Furthermore, a series of controlled experiments were performed to investigate the compatibility of Cu and Rh in a batch or a continuous flow system. Finally, the first integrated flow system using the azavinyl carbene intermediate under the tandem relay Cu/Rh dual catalysis was developed alkynes and sulfonyl azides. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | Continuous Flow Synthesis of N-Sulfonyl-1,2,3-triazoles for Tandem Relay Cu/Rh Dual Catalysis | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 88 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1200 | * |
dc.relation.lastpage | 1214 | * |
dc.relation.journaltitle | JOURNAL OF ORGANIC CHEMISTRY | * |
dc.identifier.doi | 10.1021/acs.joc.2c028081200J | * |
dc.identifier.wosid | WOS:000923829000001 | * |
dc.identifier.scopusid | 2-s2.0-85146160585 | * |
dc.author.google | Kwon, Yong-Ju | * |
dc.author.google | Lee, Sang-gi | * |
dc.author.google | Kim, Won-Suk | * |
dc.contributor.scopusid | 이상기(15082786300) | * |
dc.contributor.scopusid | 김원석(57203484044) | * |
dc.contributor.scopusid | 권용주(57192714799) | * |
dc.date.modifydate | 20240318130702 | * |