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Nonanimal Euglena gracilis-Derived Extracellular Vesicles Enhance Skin-Regenerative Wound Healing
- Title
- Nonanimal Euglena gracilis-Derived Extracellular Vesicles Enhance Skin-Regenerative Wound Healing
- Authors
- Ko, Yuri; Baek, Hwira; Hwang, Jee-Hyun; Kim, Youngseok; Lim, Kyung-Min; Kim, Junoh; Kim, Jin Woong
- Ewha Authors
- 임경민; 황지현
- SCOPUS Author ID
- 임경민; 황지현
- Issue Date
- 2023
- Journal Title
- ADVANCED MATERIALS INTERFACES
- ISSN
- 2196-7350
- Citation
- ADVANCED MATERIALS INTERFACES vol. 10, no. 4
- Keywords
- beta-glucan; Euglena gracilis; extracellular microvesicle; skin regeneration
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- This study proposes using microalgae-containing carbohydrate bioactives, an Euglena gracilis-derived extracellular microvesicle (EMVEG) system, for enhanced skin regeneration. The critical deformation ratio, 1.67, during cell extrusion enables the authors to tune the particle size of the EMVEG at asymptotic to 1 mu m, thus satisfying the encapsulation yield of beta-1,3-glucan and the cellular delivery performance. In vitro 5-bromo-2'-deoxyuridine and cell scratch assays reveal that the EMVEG promotes the proliferation and migration of skin cells, thereby increasing both collagen synthesis and the expressions of proliferation-associated proteins. An ex vivo wound-healing test using both artificial and porcine skin reveals that similar to that seen using beta-1,3-glucan, the EMVEG can substantially increase the cell population, expressing the proliferation-related protein, termed proliferating cell nuclear antigen. These results demonstrate that the EMVEG system shows considerable potential in the field of skin regeneration. This technique is expected to design new types of extracellular vesicles that are applicable for skin regeneration in the pharmaceutical and cosmetic industries.
- DOI
- 10.1002/admi.202202255
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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