Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원석 | * |
dc.date.accessioned | 2023-02-27T16:30:02Z | - |
dc.date.available | 2023-02-27T16:30:02Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1615-4150 | * |
dc.identifier.issn | 1615-4169 | * |
dc.identifier.other | OAK-33005 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/264634 | - |
dc.description.abstract | The regioselective ortho arylation of polyhalo-substituted (hetero)aryl tosylates has been investigated employing an integrated continuous flow/batch protocol. The regioselective ortho metalation of (hetero)aryl tosylates using n-BuLi and ZnCl2 was effectively achieved using continuous flow chemistry in a short residence time of 10.92 s, without removal of the tosyloxy group. The Pd-catalyzed Negishi coupling reactions of various (hetero)aryl iodides with the resulting arylzinc species proceeded readily at room temperature in 31% to 98% yields. Finally, the method was applied to the synthesis of perampanel in four linear steps, with an overall yield of 43%. | * |
dc.language | English | * |
dc.publisher | WILEY-V C H VERLAG GMBH | * |
dc.subject | Regioselective Negishi coupling | * |
dc.subject | (Hetero)aryl tosylates | * |
dc.subject | Ortho metalation | * |
dc.subject | Continuous flow chemistry | * |
dc.subject | Perampanel | * |
dc.title | Regioselective Ortho-Arylation of Polyhalo-Substituted (Hetero)Aryl Tosylates Using an Integrated Continuous Flow/Batch Protocol | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 365 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 263 | * |
dc.relation.lastpage | 268 | * |
dc.relation.journaltitle | ADVANCED SYNTHESIS & CATALYSIS | * |
dc.identifier.doi | 10.1002/adsc.202201194 | * |
dc.identifier.wosid | WOS:000913808200001 | * |
dc.identifier.scopusid | 2-s2.0-85146935354 | * |
dc.author.google | Kwon, Yong-Ju | * |
dc.author.google | Lee, Seungmi | * |
dc.author.google | Shin, Inji | * |
dc.author.google | Kim, Won-Suk | * |
dc.contributor.scopusid | 김원석(57203484044) | * |
dc.date.modifydate | 20240220102223 | * |