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A J-aggregated nanoporphyrin overcoming phototoxic side effects in superior phototherapy with two-pronged effects
- Title
- A J-aggregated nanoporphyrin overcoming phototoxic side effects in superior phototherapy with two-pronged effects
- Authors
- Yang, Mengyao; Li, Xingshu; Kim, Gyoungmi; Wang, Rui; Hong, Seong-Jin; Lee, Chang-Hee; Yoon, Juyoung
- Ewha Authors
- 윤주영
- SCOPUS Author ID
- 윤주영
- Issue Date
- 2022
- Journal Title
- CHEMICAL SCIENCE
- ISSN
- 2041-6520
2041-6539
- Citation
- CHEMICAL SCIENCE vol. 13, no. 43, pp. 12738 - 12746
- Publisher
- ROYAL SOC CHEMISTRY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Phototherapy has been a promising therapeutic modality for pathological tissue due to its spatiotemporal selectivity and non-invasive characteristics. However, as a core component of phototherapy, a single photosensitizer (PS) nanoplatform integrating excellent therapeutic efficiency and minimal side effects remains an urgent but unmet need. Here, we construct a J-aggregated nano-porphyrin termed MTE based on the self-assembly of methyl-pheophorbide a derivative MPa-TEG (MT) and natural polyphenolic compound epigallocatechin gallate (EGCG). Due to the synergistic interaction between similar large pi-conjugated structural EGCG and MT, MTE with small and uniform size is obtained by effectively hindering Ostwald ripening of MT. Noteworthily, MTE not only effectively avoids the inadvertent side effects of phototoxicity during transport thank to the ability of reactive oxygen species (ROS) scavenging, but also achieves two-pathway augmented superior phototherapy: (1) enhancing photodynamic therapy (PDT) via inhibiting the expression of anti-apoptosis protein surviving; (2) achieving adjuvant mild-temperature laser interstitial thermal therapy (LITT) via reducing the tumor thermoresistance on account that MTE inhibits the overexpression of HSP 70 and HSP 90. This research not only offers a facile strategy to construct multicomponent nanoplatforms but also provides a new pathway for efficient and low-toxicity phototherapy, which is beneficial to the future clinical application.
- DOI
- 10.1039/d2sc04873f
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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