NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
약학대학
약학과
Journal papers
View : 312 Download: 68
Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1
Title
Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1
Authors
Chung S.
;
Kang M.-S.
;
Alimbetov D.S.
;
Mun G.-I.
;
Yunn N.-O.
;
Kim Y.
;
Kim B.-G.
;
Wie M.
;
Lee E.A.
;
Ra J.S.
;
Oh J.-M.
;
Lee D.
;
Lee K.
;
Kim J.
;
Han S.H.
;
Kim K.-T.
;
Chung W.K.
;
Nam K.H.
;
Park J.
;
Lee B.H.
;
Kim S.
;
Zhao W.
;
Ryu S.H.
;
Lee Y.-S.
;
Myung K.
;
Cho Y.
Ewha Authors
이윤실
;
문길임
SCOPUS Author ID
이윤실
; 문길임
Issue Date
2022
Journal Title
Nature Communications
ISSN
2041-1723
Citation
Nature Communications vol. 13, no. 1
Publisher
Nature Research
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
Aminoacyl-tRNA synthetases (ARSs) have evolved to acquire various additional domains. These domains allow ARSs to communicate with other cellular proteins in order to promote non-translational functions. Vertebrate cytoplasmic isoleucyl-tRNA synthetases (IARS1s) have an uncharacterized unique domain, UNE-I. Here, we present the crystal structure of the chicken IARS1 UNE-I complexed with glutamyl-tRNA synthetase 1 (EARS1). UNE-I consists of tandem ubiquitin regulatory X (UBX) domains that interact with a distinct hairpin loop on EARS1 and protect its neighboring proteins in the multi-synthetase complex from degradation. Phosphomimetic mutation of the two serine residues in the hairpin loop releases IARS1 from the complex. IARS1 interacts with BRCA1 in the nucleus, regulates its stability by inhibiting ubiquitylation via the UBX domains, and controls DNA repair function. © 2022, The Author(s).
DOI
10.1038/s41467-022-34612-y
Appears in Collections:
약학대학
>
약학과
>
Journal papers
Files in This Item:
s41467-022-34612-y.pdf
(2.21 MB)
Download
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject