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Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial
- Title
- Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial
- Authors
- Nam H.S.; Kim Y.D.; Choi J.K.; Baik M.; Kim B.M.; Kim D.J.; Heo J.; Shin D.H.; Lee K.-Y.; Jung Y.H.; Baek J.-H.; Hwang Y.-H.; Sohn S.-I.; Hong J.-H.; Park H.; Kim C.K.; Kim G.S.; Seo K.-D.; Lee K.; Seo J.H.; Bang O.Y.; Seo W.-K.; Chung J.-W.; Chang J.Y.; Kwon S.U.; Lee J.; Kim J.; Yoo J.; Song T.-J.; Ahn S.H.; Cho B.-H.; Cho H.-J.; Kim J.G.; Chang Y.; Lee C.J.; Park S.; Park G.; Lee H.S.
- Ewha Authors
- 송태진; 장윤경
- SCOPUS Author ID
- 송태진
; 장윤경![scopus](/images/layout/icon2.png)
- Issue Date
- 2022
- Journal Title
- International Journal of Stroke
- ISSN
- 1747-4930
- Citation
- International Journal of Stroke vol. 17, no. 8, pp. 931 - 937
- Keywords
- blood pressure; cerebral infarction; outcome research; Reperfusion therapy
- Publisher
- SAGE Publications Inc.
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Rationale: Very early stage blood pressure (BP) levels may affect outcome in stroke patients who have successfully undergone recanalization following intra-arterial treatment, but the optimal target of BP management remains uncertain. Aim: We hypothesized that the clinical outcome after intensive BP-lowering is superior to conventional BP control after successful recanalization by intra-arterial treatment. Sample-size estimates: We aim to randomize 668 patients (334 per arm), 1:1. Methods and design: We initiated a multicenter, prospective, randomized, open-label trial with a blinded end-point assessment (PROBE) design. After successful recanalization (thrombolysis in cerebral infarction score ≥ 2 b), patients with elevated systolic BP level, defined as the mean of two readings ≥ 140 mmHg, will be randomly assigned to the intensive BP-lowering (systolic BP < 140 mm Hg) group or the conventional BP-lowering (systolic BP, 140−180 mm Hg) group. Study outcomes: The primary efficacy outcomes are from dichotomized analysis of modified Rankin Scale (mRS) scores at three months (mRS scores: 0–2 vs. 3–6). The primary safety outcomes are symptomatic intracerebral hemorrhage and death within three months. Discussion: The OPTIMAL-BP trial will provide evidence for the effectiveness of active BP control to achieve systolic BP < 140 mmHg during 24 h in patients with successful recanalization after intra-arterial treatment. Clinical trial registration: ClinicalTrials.gov Identifier: NCT04205305. © 2021 World Stroke Organization.
- DOI
- 10.1177/17474930211041213
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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