Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송태진 | * |
dc.contributor.author | 장윤경 | * |
dc.date.accessioned | 2022-11-03T16:31:11Z | - |
dc.date.available | 2022-11-03T16:31:11Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1747-4930 | * |
dc.identifier.other | OAK-32433 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/262904 | - |
dc.description.abstract | Rationale: Very early stage blood pressure (BP) levels may affect outcome in stroke patients who have successfully undergone recanalization following intra-arterial treatment, but the optimal target of BP management remains uncertain. Aim: We hypothesized that the clinical outcome after intensive BP-lowering is superior to conventional BP control after successful recanalization by intra-arterial treatment. Sample-size estimates: We aim to randomize 668 patients (334 per arm), 1:1. Methods and design: We initiated a multicenter, prospective, randomized, open-label trial with a blinded end-point assessment (PROBE) design. After successful recanalization (thrombolysis in cerebral infarction score ≥ 2 b), patients with elevated systolic BP level, defined as the mean of two readings ≥ 140 mmHg, will be randomly assigned to the intensive BP-lowering (systolic BP < 140 mm Hg) group or the conventional BP-lowering (systolic BP, 140−180 mm Hg) group. Study outcomes: The primary efficacy outcomes are from dichotomized analysis of modified Rankin Scale (mRS) scores at three months (mRS scores: 0–2 vs. 3–6). The primary safety outcomes are symptomatic intracerebral hemorrhage and death within three months. Discussion: The OPTIMAL-BP trial will provide evidence for the effectiveness of active BP control to achieve systolic BP < 140 mmHg during 24 h in patients with successful recanalization after intra-arterial treatment. Clinical trial registration: ClinicalTrials.gov Identifier: NCT04205305. © 2021 World Stroke Organization. | * |
dc.language | English | * |
dc.publisher | SAGE Publications Inc. | * |
dc.subject | blood pressure | * |
dc.subject | cerebral infarction | * |
dc.subject | outcome research | * |
dc.subject | Reperfusion therapy | * |
dc.title | Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 17 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 931 | * |
dc.relation.lastpage | 937 | * |
dc.relation.journaltitle | International Journal of Stroke | * |
dc.identifier.doi | 10.1177/17474930211041213 | * |
dc.identifier.scopusid | 2-s2.0-85113924080 | * |
dc.author.google | Nam H.S. | * |
dc.author.google | Kim Y.D. | * |
dc.author.google | Choi J.K. | * |
dc.author.google | Baik M. | * |
dc.author.google | Kim B.M. | * |
dc.author.google | Kim D.J. | * |
dc.author.google | Heo J. | * |
dc.author.google | Shin D.H. | * |
dc.author.google | Lee K.-Y. | * |
dc.author.google | Jung Y.H. | * |
dc.author.google | Baek J.-H. | * |
dc.author.google | Hwang Y.-H. | * |
dc.author.google | Sohn S.-I. | * |
dc.author.google | Hong J.-H. | * |
dc.author.google | Park H. | * |
dc.author.google | Kim C.K. | * |
dc.author.google | Kim G.S. | * |
dc.author.google | Seo K.-D. | * |
dc.author.google | Lee K. | * |
dc.author.google | Seo J.H. | * |
dc.author.google | Bang O.Y. | * |
dc.author.google | Seo W.-K. | * |
dc.author.google | Chung J.-W. | * |
dc.author.google | Chang J.Y. | * |
dc.author.google | Kwon S.U. | * |
dc.author.google | Lee J. | * |
dc.author.google | Kim J. | * |
dc.author.google | Yoo J. | * |
dc.author.google | Song T.-J. | * |
dc.author.google | Ahn S.H. | * |
dc.author.google | Cho B.-H. | * |
dc.author.google | Cho H.-J. | * |
dc.author.google | Kim J.G. | * |
dc.author.google | Chang Y. | * |
dc.author.google | Lee C.J. | * |
dc.author.google | Park S. | * |
dc.author.google | Park G. | * |
dc.author.google | Lee H.S. | * |
dc.contributor.scopusid | 송태진(55507164200) | * |
dc.contributor.scopusid | 장윤경(56525550900) | * |
dc.date.modifydate | 20240315140840 | * |