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자연과학대학
생명과학전공
Journal papers
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NADPH oxidase inhibitor development for diabetic nephropathy through water tank model
Title
NADPH oxidase inhibitor development for diabetic nephropathy through water tank model
Authors
Lee H.E.
;
Shim S.
;
Choi Y.
;
Bae Y.S.
Ewha Authors
배윤수
SCOPUS Author ID
배윤수
Issue Date
2022
Journal Title
Kidney Research and Clinical Practice
ISSN
2211-9132
Citation
Kidney Research and Clinical Practice vol. 41, pp. S89 - S98
Keywords
Diabetic nephropathies
;
NADPH oxidases
;
Nox inhibitor
;
Oxidative stress
;
Reactive oxygen species
Publisher
The Korean Society of Nephrology
Indexed
SCIE; SCOPUS; KCI
Document Type
Review
Abstract
Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated cell signaling. Although excessive levels of ROS are harmful, moderated levels of ROS are essential for normal physiological function. Therefore, regulating cellular ROS levels should be an important concept for development of novel therapeutics for treating diseases. The overexpression and hyperactivation of NADPH oxidase (Nox) can induce high levels of ROS, which are strongly associated with diabetic nephropathy. This review discusses the theoretical basis for development of the Nox inhibitor as a regulator of ROS homeostasis to provide emerging therapeutic opportunities for diabetic nephropathy. © 2022 by The Korean Society of Nephrology.
DOI
10.23876/j.krcp.21.269
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