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Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp
- Title
- Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp
- Authors
- Kim, Sohee; Hillman, Prima F.; Lee, Ji Young; Lee, Juri; Lee, Jihye; Cha, Sun-Shin; Oh, Dong-Chan; Nam, Sang-Jip; Fenical, William
- Ewha Authors
- 남상집; 차선신
- SCOPUS Author ID
- 남상집; 차선신
- Issue Date
- 2022
- Journal Title
- JOURNAL OF ANTIBIOTICS
- ISSN
- 0021-8820
1881-1469
- Citation
- JOURNAL OF ANTIBIOTICS vol. 75, no. 11, pp. 619 - 625
- Publisher
- SPRINGERNATURE
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1-3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 mu g ml(-1), respectively.
- DOI
- 10.1038/s41429-022-00562-2
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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