Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이용현 | * |
dc.date.accessioned | 2022-10-27T16:31:12Z | - |
dc.date.available | 2022-10-27T16:31:12Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1999-4923 | * |
dc.identifier.other | OAK-32356 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/262660 | - |
dc.description.abstract | RNA interference (RNAi) therapies have significant potential for the treatment of inflammatory bowel diseases (IBD). Although administering small interfering RNA (siRNA) via an oral route is desirable, various hurdles including physicochemical, mucus, and cellular uptake barriers of the gastrointestinal tract (GIT) impede both the delivery of siRNA to the target site and the action of siRNA drugs at the target site. In this review, we first discuss various physicochemical and biological barriers in the GI tract. Furthermore, we present recent strategies and the progress of oral siRNA delivery strategies to treat IBD. Finally, we consider the challenges faced in the use of these strategies and future directions of oral siRNA delivery strategies. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | oral drug delivery | * |
dc.subject | siRNA | * |
dc.subject | inflammatory bowel disease | * |
dc.subject | gene delivery | * |
dc.subject | nanomedicines | * |
dc.subject | Immunotherapy | * |
dc.title | Oral Nanomedicines for siRNA Delivery to Treat Inflammatory Bowel Disease | * |
dc.type | Review | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 14 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | PHARMACEUTICS | * |
dc.identifier.doi | 10.3390/pharmaceutics14091969 | * |
dc.identifier.wosid | WOS:000859522500001 | * |
dc.identifier.scopusid | 2-s2.0-85138667317 | * |
dc.author.google | Shinn, Jongyoon | * |
dc.author.google | Lee, Juyeon | * |
dc.author.google | Lee, Seon Ah | * |
dc.author.google | Lee, Seon Ju | * |
dc.author.google | Choi, Ah Hyun | * |
dc.author.google | Kim, Jung Seo | * |
dc.author.google | Kim, Su Jin | * |
dc.author.google | Kim, Hyo Jin | * |
dc.author.google | Lee, Cherin | * |
dc.author.google | Kim, Yejin | * |
dc.author.google | Kim, Joohyeon | * |
dc.author.google | Choi, Jonghee | * |
dc.author.google | Jung, Byungchae | * |
dc.author.google | Kim, Taeho | * |
dc.author.google | Nam, HyeonTaek | * |
dc.author.google | Kim, Hyungjun | * |
dc.author.google | Lee, Yonghyun | * |
dc.contributor.scopusid | 이용현(38561637800) | * |
dc.date.modifydate | 20231214111942 | * |