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Mesenchymal Stem Cell-Mediated Deep Tumor Delivery of Gold Nanorod for Photothermal Therapy
- Title
- Mesenchymal Stem Cell-Mediated Deep Tumor Delivery of Gold Nanorod for Photothermal Therapy
- Authors
- Yun, Wan Su; Shim, Man Kyu; Lim, Seungho; Song, Sukyung; Kim, Jinseong; Yang, Suah; Hwang, Hee Sook; Kim, Mi Ra; Yoon, Hong Yeol; Lim, Dong-Kwon; Sun, In-Cheol; Kim, Kwangmeyung
- Ewha Authors
- 김광명
- SCOPUS Author ID
- 김광명
- Issue Date
- 2022
- Journal Title
- NANOMATERIALS
- ISSN
- 2079-4991
- Citation
- NANOMATERIALS vol. 12, no. 19
- Keywords
- mesenchymal stem cell; gold nanorod; drug delivery; deep tumor penetration; photothermal therapy
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Gold nanoparticles (AuNPs) with various sizes and morphologies have been extensively investigated for effective photothermal therapy (PTT) against multiple cancer types. However, a highly dynamic and complex tumor microenvironment (TME) considerably reduces the efficacy of PTT by limiting deep tumor penetration of AuNPs. Herein, we propose a mesenchymal stem cell (MSC)-mediated deep tumor delivery of gold nanorod (AuNR) for a potent PTT. First, MSCs are treated with tetraacylated N-azidomannosamine (Ac(4)ManNAz) to introduce modifiable azide (N-3) groups on the cell surface via metabolic glycoengineering. Then, AuNRs modified with bio-orthogonal click molecules of bicyclo[6.1.0]nonyne (AuNR@BCN) are chemically conjugated to the N-3 groups on the MSC surface by copper-free click chemistry reaction, resulting in AuNR@MSCs. In cultured MSCs, the appropriate condition to incorporate the AuNR into the MSCs is optimized; in addition, the photothermal efficiency of AuNR-MSCs under light irradiation are assessed, showing efficient heat generation in vitro. In colon tumor-bearing mice, intravenously injected AuNR@MSCs efficiently accumulate within the tumor tissues by allowing deep tissue penetration owing to the tumor homing effect by natural tumor tropism of AuNR@MSCs. Upon localized light irradiation, the AuNR@MSCs significantly inhibit colon tumor growth by the enhanced photothermal effect compared to conventional AuNRs. Collectively, this study shows a promising approach of MSCs-mediated deep tumor delivery of AuNR for effective PTT.
- DOI
- 10.3390/nano12193410
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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nanomaterials-12-03410-v2.pdf(1.7 MB)
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