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Association of Gender With Clinical Outcomes in a Contemporary Cohort of Patients With Atrial Fibrillation Receiving Oral Anticoagulants
- Title
- Association of Gender With Clinical Outcomes in a Contemporary Cohort of Patients With Atrial Fibrillation Receiving Oral Anticoagulants
- Authors
- Kim, Minjeong; Kim, Jun; Kim, Jin-Bae; Park, Junbeom; Park, Jin-Kyu; Kang, Ki-Woon; Shim, Jaemin; Choi, Eue-Keun; Lee, Young Soo; Park, Hyung Wook; Joung, Boyoung
- Ewha Authors
- 박준범
- SCOPUS Author ID
- 박준범
- Issue Date
- 2022
- Journal Title
- KOREAN CIRCULATION JOURNAL
- ISSN
- 1738-5520
1738-5555
- Citation
- KOREAN CIRCULATION JOURNAL vol. 52, no. 8, pp. 593 - 603
- Keywords
- Atrial fibrillation; Female; Anticoagulants
- Publisher
- KOREAN SOC CARDIOLOGY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Background and Objectives: In patients with atrial fibrillation (AF), females taking vitamin K antagonist are at higher risk of stroke or systemic embolism (SSE), bleeding and all-cause death than males. This study investigated the relationship between sex and adverse clinical events in a contemporary AF patient cohort taking anticoagulation. Methods: This prospective multicenter AF registry study comprised 6,067 patients with AF (mean age, 70 +/- 9 years; men, 59%) with intermediate to high risk of stroke (CHA(2)DS(2)-VAscore >= 1) and receiving oral anticoagulation therapy. Adverse clinical outcomes, including SSE, bleeding, death were evaluated in patients stratified by sex and anticoagulation patterns. Results: Women were older and used more direct oral anticoagulants (85% vs. 78%, p< 0.001) than men. During a median (25(th) and 75(th) percentiles) follow-up of 30 (24, 38) months, the incidence rate and risk of SSE (0.7 in women vs. 0.7 in men per 100 person-years) and major bleeding (0.1 in women vs. 0.1 in men per 100 person-years) were not different between the sexes. However, women had a lower all-cause death rate (0.4 in women vs. 0.6 in men per 100 person-years, hazard ratio: 0.48, 95% confidence interval: 0.25-0.91, p=0.025) than men. Conclusions: In contemporary anticoagulation for AF, SSE and major bleeding risks did not differ between sexes. However, women showed a lower risk of all-cause death rate than men, indicating that the use of oral anticoagulants for treating AF in females does not appear to be a risk factor for adverse clinical events.
- DOI
- 10.4070/kcj.2021.0399
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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