Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박준범 | * |
dc.date.accessioned | 2022-08-12T16:31:27Z | - |
dc.date.available | 2022-08-12T16:31:27Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1738-5520 | * |
dc.identifier.issn | 1738-5555 | * |
dc.identifier.other | OAK-32071 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/262438 | - |
dc.description.abstract | Background and Objectives: In patients with atrial fibrillation (AF), females taking vitamin K antagonist are at higher risk of stroke or systemic embolism (SSE), bleeding and all-cause death than males. This study investigated the relationship between sex and adverse clinical events in a contemporary AF patient cohort taking anticoagulation. Methods: This prospective multicenter AF registry study comprised 6,067 patients with AF (mean age, 70 +/- 9 years; men, 59%) with intermediate to high risk of stroke (CHA(2)DS(2)-VAscore >= 1) and receiving oral anticoagulation therapy. Adverse clinical outcomes, including SSE, bleeding, death were evaluated in patients stratified by sex and anticoagulation patterns. Results: Women were older and used more direct oral anticoagulants (85% vs. 78%, p< 0.001) than men. During a median (25(th) and 75(th) percentiles) follow-up of 30 (24, 38) months, the incidence rate and risk of SSE (0.7 in women vs. 0.7 in men per 100 person-years) and major bleeding (0.1 in women vs. 0.1 in men per 100 person-years) were not different between the sexes. However, women had a lower all-cause death rate (0.4 in women vs. 0.6 in men per 100 person-years, hazard ratio: 0.48, 95% confidence interval: 0.25-0.91, p=0.025) than men. Conclusions: In contemporary anticoagulation for AF, SSE and major bleeding risks did not differ between sexes. However, women showed a lower risk of all-cause death rate than men, indicating that the use of oral anticoagulants for treating AF in females does not appear to be a risk factor for adverse clinical events. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC CARDIOLOGY | * |
dc.subject | Atrial fibrillation | * |
dc.subject | Female | * |
dc.subject | Anticoagulants | * |
dc.title | Association of Gender With Clinical Outcomes in a Contemporary Cohort of Patients With Atrial Fibrillation Receiving Oral Anticoagulants | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 52 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 593 | * |
dc.relation.lastpage | 603 | * |
dc.relation.journaltitle | KOREAN CIRCULATION JOURNAL | * |
dc.identifier.doi | 10.4070/kcj.2021.0399 | * |
dc.identifier.wosid | WOS:000897010500003 | * |
dc.identifier.scopusid | 2-s2.0-85131363648 | * |
dc.author.google | Kim, Minjeong | * |
dc.author.google | Kim, Jun | * |
dc.author.google | Kim, Jin-Bae | * |
dc.author.google | Park, Junbeom | * |
dc.author.google | Park, Jin-Kyu | * |
dc.author.google | Kang, Ki-Woon | * |
dc.author.google | Shim, Jaemin | * |
dc.author.google | Choi, Eue-Keun | * |
dc.author.google | Lee, Young Soo | * |
dc.author.google | Park, Hyung Wook | * |
dc.author.google | Joung, Boyoung | * |
dc.contributor.scopusid | 박준범(55131469900) | * |
dc.date.modifydate | 20240429132147 | * |