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Facile synthetic method for peptoids bearing multiple azoles on side chains
- Title
- Facile synthetic method for peptoids bearing multiple azoles on side chains
- Authors
- Lee Y.J.; Park S.; Kim Y.; Kim S.H.; Seo J.
- Ewha Authors
- 김선희
- SCOPUS Author ID
- 김선희
- Issue Date
- 2022
- Journal Title
- Peptide Science
- ISSN
- 2475-8817
- Citation
- Peptide Science
- Keywords
- 1,2,3-triazole; azole; imidazole; metal ligand; nucleophilic substitution; peptoid; pyrazole; tetrazole
- Publisher
- John Wiley and Sons Inc
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Natural metalloenzymes stabilize metal centers by utilizing multiple imidazole moieties. Inspired by nature's design principles, the introduction of multiple azoles into ligands has been an effective method for constructing transition metal complexes. Herein, we describe a post-synthetic modification of peptoids to incorporate multiple azoles on side chains. A simple substitution reaction between an azole (imidazole, pyrazole, 1,2,3-triazole, and tetrazole) and a chloroalkyl-containing peptoid provided access to a variety of azole-containing peptoids. Ten azole-containing peptoids were synthesized from a single chloroalkyl-containing peptoid, and the efficiency of each azole for the substitution reaction was evaluated. We have identified that several of the azole-containing peptoids are capable of binding with Cu(II) and Fe(III). Our synthetic approach can contribute to the expansion of peptoids' chemical diversity and the development of novel peptoids for metal recognition and catalysis. © 2022 Wiley Periodicals LLC.
- DOI
- 10.1002/pep2.24287
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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