Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.date.accessioned | 2022-08-02T16:30:48Z | - |
dc.date.available | 2022-08-02T16:30:48Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2041-6520 | * |
dc.identifier.other | OAK-31795 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261674 | - |
dc.description.abstract | Construction of an activatable photosensitizer and integration into an adaptive nanozyme during phototherapy without producing off-target toxicity remains a challenge. Herein, we have fabricated a prodrug-like supramolecular nanozyme based on a metallic-curcumin and cyanine co-assembly. The albumin-mediated phenol AOH group transformation of nanozyme changes its adjustable oxygen stress from negative superoxide dismutase-like activity of ROS-scavenging to positive photo oxidase activity with an ROS-amplifying capacity. It further increases the depth penetration of a nanozyme in a tumor spheroid, selectively targeting tumorous phototherapy. It also triggers a signal in targeted tumor cells and helps increase cancer cell ablation. This work suggests new options for development of activatable supramolecular nanozymes and provides a synergetic prodrug-like nanozyme strategy for early diagnosis and preclinical phototherapeutics. © 2022 The Royal Society of Chemistry. | * |
dc.language | English | * |
dc.publisher | Royal Society of Chemistry | * |
dc.title | Albumin-mediated “Unlocking” of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy | * |
dc.type | Article | * |
dc.relation.issue | 26 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 7814 | * |
dc.relation.lastpage | 7820 | * |
dc.relation.journaltitle | Chemical Science | * |
dc.identifier.doi | 10.1039/d2sc02025d | * |
dc.identifier.wosid | WOS:000811778000001 | * |
dc.identifier.scopusid | 2-s2.0-85132695109 | * |
dc.author.google | Han J. | * |
dc.author.google | Li H. | * |
dc.author.google | Zhao L. | * |
dc.author.google | Kim G. | * |
dc.author.google | Chen Y. | * |
dc.author.google | Yan X. | * |
dc.author.google | Yoon J. | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |