View : 310 Download: 0
Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer
- Title
- Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer
- Authors
- Jung, Hye-Kyung; Tae, Chung Hyun; Lee, Hye Ah; Lee, Ko Eun; Moon, Chang Mo; Kim, Seong Eun; Seoh, Ju Young; Lee, Joo-Ho
- Ewha Authors
- 서주영; 정혜경; 이주호; 김성은; 문창모; 태정현; 이혜아
- SCOPUS Author ID
- 서주영; 정혜경; 이주호; 김성은; 문창모; 태정현; 이혜아
- Issue Date
- 2022
- Journal Title
- JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
- ISSN
- 2093-0879
2093-0887
- Citation
- JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY vol. 28, no. 3, pp. 409 - 417
- Keywords
- Gastrectomy; Ghrelin; Glucagon-like peptide-1; Stomach neoplasms; Weight loss
- Publisher
- KOREAN SOC NEUROGASTROENTEROLOGY &
MOTILITY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Background/Aims Post-operative weight loss in patients with gastric cancer lead to a poor quality of life and long-term survival. This study aims to evaluate the effects of gut regulatory hormones on post-operative weight loss in patients with subtotal gastrectomy for gastric cancer. Methods This prospective study was conducted for 12 months post-surgery in 14 controls and 13 gastrectomy patients who underwent subtotal gastrectomy for gastric cancer. Serum plasma ghrelin, glucagon-like peptide-1, gastric inhibitory peptide-1, peptide YY, insulin, and homeostatic model assessment for insulin resistance responses to a standardized test meal were recorded at multiple time points before and after gastrectomy at 4 and 12 months. Results The mean weight difference between the pre-operative state and the 4-month period was significantly reduced to 6.6 kg (P = 0.032), but significant weight reduction was not observed from 4 months to 12 months. The plasma levels of glucagon-like peptide-1, gastric inhibitory peptide-1, and peptide YY were significantly increased 4 months postoperatively compared to the pre-operative state (all P = 0.035); however, pre-operative levels and relative changes over a period of 0-4 months of hormones were not correlated with body weight changes. Only the pre-operative ghrelin at peak had a negative correlation with changes in weight reduction in the 4 months after surgery (rho = -0.8, P = 0.024). Conclusions Significant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes.
- DOI
- 10.5056/jnm21145
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML