Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서주영 | * |
dc.contributor.author | 정혜경 | * |
dc.contributor.author | 이주호 | * |
dc.contributor.author | 김성은 | * |
dc.contributor.author | 문창모 | * |
dc.contributor.author | 태정현 | * |
dc.contributor.author | 이혜아 | * |
dc.date.accessioned | 2022-08-02T16:30:04Z | - |
dc.date.available | 2022-08-02T16:30:04Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2093-0879 | * |
dc.identifier.issn | 2093-0887 | * |
dc.identifier.other | OAK-31852 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261620 | - |
dc.description.abstract | Background/Aims Post-operative weight loss in patients with gastric cancer lead to a poor quality of life and long-term survival. This study aims to evaluate the effects of gut regulatory hormones on post-operative weight loss in patients with subtotal gastrectomy for gastric cancer. Methods This prospective study was conducted for 12 months post-surgery in 14 controls and 13 gastrectomy patients who underwent subtotal gastrectomy for gastric cancer. Serum plasma ghrelin, glucagon-like peptide-1, gastric inhibitory peptide-1, peptide YY, insulin, and homeostatic model assessment for insulin resistance responses to a standardized test meal were recorded at multiple time points before and after gastrectomy at 4 and 12 months. Results The mean weight difference between the pre-operative state and the 4-month period was significantly reduced to 6.6 kg (P = 0.032), but significant weight reduction was not observed from 4 months to 12 months. The plasma levels of glucagon-like peptide-1, gastric inhibitory peptide-1, and peptide YY were significantly increased 4 months postoperatively compared to the pre-operative state (all P = 0.035); however, pre-operative levels and relative changes over a period of 0-4 months of hormones were not correlated with body weight changes. Only the pre-operative ghrelin at peak had a negative correlation with changes in weight reduction in the 4 months after surgery (rho = -0.8, P = 0.024). Conclusions Significant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC NEUROGASTROENTEROLOGY & | * |
dc.publisher | MOTILITY | * |
dc.subject | Gastrectomy | * |
dc.subject | Ghrelin | * |
dc.subject | Glucagon-like peptide-1 | * |
dc.subject | Stomach neoplasms | * |
dc.subject | Weight loss | * |
dc.title | Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 28 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 409 | * |
dc.relation.lastpage | 417 | * |
dc.relation.journaltitle | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY | * |
dc.identifier.doi | 10.5056/jnm21145 | * |
dc.identifier.wosid | WOS:000826979300002 | * |
dc.author.google | Jung, Hye-Kyung | * |
dc.author.google | Tae, Chung Hyun | * |
dc.author.google | Lee, Hye Ah | * |
dc.author.google | Lee, Ko Eun | * |
dc.author.google | Moon, Chang Mo | * |
dc.author.google | Kim, Seong Eun | * |
dc.author.google | Seoh, Ju Young | * |
dc.author.google | Lee, Joo-Ho | * |
dc.contributor.scopusid | 서주영(6603709174;57209001625) | * |
dc.contributor.scopusid | 정혜경(7403029723) | * |
dc.contributor.scopusid | 이주호(55689891300) | * |
dc.contributor.scopusid | 김성은(35210756100;57204243828) | * |
dc.contributor.scopusid | 문창모(8131765500) | * |
dc.contributor.scopusid | 태정현(35211966400) | * |
dc.contributor.scopusid | 이혜아(57188947704) | * |
dc.date.modifydate | 20240422125929 | * |