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Plasma osteoprotegerin level is associated with hemorrhagic transformation in stroke patients who underwent endovascular thrombectomy
- Title
- Plasma osteoprotegerin level is associated with hemorrhagic transformation in stroke patients who underwent endovascular thrombectomy
- Authors
- Kim H.J.; Park M.-S.; Joo A.; Kang S.; Eum S.; Chang Y.; Song T.-J.
- Ewha Authors
- 송태진; 장윤경; 김형준; 박무석
- SCOPUS Author ID
- 송태진; 장윤경; 김형준; 박무석
- Issue Date
- 2022
- Journal Title
- Clinical Neurology and Neurosurgery
- ISSN
- 0303-8467
- Citation
- Clinical Neurology and Neurosurgery vol. 219
- Keywords
- Osteoprotegerin; Prognosis; Stroke; Thrombectomy
- Publisher
- Elsevier B.V.
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objective: Osteoprotegerin (OPG) is a component of the tumor necrosis factor receptor superfamily. Several studies have shown a relationship between OPG and cardiovascular disease. We investigated the association between plasma OPG levels and hemorrhagic transformation in stroke patients who received endovascular thrombectomy (EVT). Methods: We prospectively enrolled 360 patients diagnosed with acute ischemic stroke and performed EVT from April 2014 to December 2020. Blood sampling for plasma OPG was performed after fasting for 12 h after EVT. Hemorrhagic transformation was defined using the definition and classification of the European Cooperative Acute Stroke Study-3 trial. Results: Of all the included patients, 130 (36.1%) experienced hemorrhagic transformation. The mean ± standard deviation of the plasma OPG concentrations was 200.2 ± 74.4 pg/mL. In multivariable analysis, after adjusting for age, sex, body mass index (BMI), and variables with p < 0.1 in univariable analysis (diabetes mellitus, atrial fibrillation, coronary artery disease, alcohol intake, current smoking, NIHSS, ASPECT score, mass effect, hemoglobin, vitamin D 25(OH)D), increased plasma OPG concentration was independently related to any hemorrhagic transformation (highest tertile vs. lowest tertile of OPG; odds ratio [OR] 2.31, 95% confidence interval [CI] (1.29–4.14), p = 0.005) and severity of hemorrhagic transformation (OR 2.92, 95% CI (1.66–5.12), p = 0.001). Conclusions: Our results demonstrate that increased plasma OPG level is related to the occurrence and severity of hemorrhagic transformation in patients with cerebral infarction who receive EVT. © 2022
- DOI
- 10.1016/j.clineuro.2022.107305
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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