Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송태진 | * |
dc.contributor.author | 장윤경 | * |
dc.contributor.author | 김형준 | * |
dc.contributor.author | 박무석 | * |
dc.date.accessioned | 2022-07-14T16:30:58Z | - |
dc.date.available | 2022-07-14T16:30:58Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 0303-8467 | * |
dc.identifier.other | OAK-31667 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261509 | - |
dc.description.abstract | Objective: Osteoprotegerin (OPG) is a component of the tumor necrosis factor receptor superfamily. Several studies have shown a relationship between OPG and cardiovascular disease. We investigated the association between plasma OPG levels and hemorrhagic transformation in stroke patients who received endovascular thrombectomy (EVT). Methods: We prospectively enrolled 360 patients diagnosed with acute ischemic stroke and performed EVT from April 2014 to December 2020. Blood sampling for plasma OPG was performed after fasting for 12 h after EVT. Hemorrhagic transformation was defined using the definition and classification of the European Cooperative Acute Stroke Study-3 trial. Results: Of all the included patients, 130 (36.1%) experienced hemorrhagic transformation. The mean ± standard deviation of the plasma OPG concentrations was 200.2 ± 74.4 pg/mL. In multivariable analysis, after adjusting for age, sex, body mass index (BMI), and variables with p < 0.1 in univariable analysis (diabetes mellitus, atrial fibrillation, coronary artery disease, alcohol intake, current smoking, NIHSS, ASPECT score, mass effect, hemoglobin, vitamin D 25(OH)D), increased plasma OPG concentration was independently related to any hemorrhagic transformation (highest tertile vs. lowest tertile of OPG; odds ratio [OR] 2.31, 95% confidence interval [CI] (1.29–4.14), p = 0.005) and severity of hemorrhagic transformation (OR 2.92, 95% CI (1.66–5.12), p = 0.001). Conclusions: Our results demonstrate that increased plasma OPG level is related to the occurrence and severity of hemorrhagic transformation in patients with cerebral infarction who receive EVT. © 2022 | * |
dc.language | English | * |
dc.publisher | Elsevier B.V. | * |
dc.subject | Osteoprotegerin | * |
dc.subject | Prognosis | * |
dc.subject | Stroke | * |
dc.subject | Thrombectomy | * |
dc.title | Plasma osteoprotegerin level is associated with hemorrhagic transformation in stroke patients who underwent endovascular thrombectomy | * |
dc.type | Article | * |
dc.relation.volume | 219 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Clinical Neurology and Neurosurgery | * |
dc.identifier.doi | 10.1016/j.clineuro.2022.107305 | * |
dc.identifier.wosid | WOS:000808261500001 | * |
dc.identifier.scopusid | 2-s2.0-85131600386 | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Park M.-S. | * |
dc.author.google | Joo A. | * |
dc.author.google | Kang S. | * |
dc.author.google | Eum S. | * |
dc.author.google | Chang Y. | * |
dc.author.google | Song T.-J. | * |
dc.contributor.scopusid | 송태진(55507164200) | * |
dc.contributor.scopusid | 장윤경(56525550900) | * |
dc.contributor.scopusid | 김형준(57329146300;55635231700) | * |
dc.contributor.scopusid | 박무석(56428268200;57330111500) | * |
dc.date.modifydate | 20240315140840 | * |