Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 오억수 | - |
dc.contributor.author | 황지선 | - |
dc.contributor.author | 장보희 | - |
dc.date.accessioned | 2022-07-14T16:30:57Z | - |
dc.date.available | 2022-07-14T16:30:57Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.other | OAK-31670 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261506 | - |
dc.description.abstract | We previously showed that a synthetic peptide (S2-P) corresponding to a portion of the human syndecan-2 (SDC2) sequence can bind to the pro-domain of matrix metalloproteinase-7 (MMP-7) to inhibit colon cancer activities. Since S2-P had a relatively weak binding affinity for the MMP-7 pro-domain, we herein modified the amino acid sequence of S2-P to improve the anticancer potential. On the basis of the interaction structure of S2-P and MMP-7, four peptides were generated by replacing amino acids near Tyr 51, which is critical for the interaction. The SDC2-mimetic peptides harboring an Ala-to-Asp substitution at the C-terminal side of Tyr 51 (S2-D) or with an Ala-to-Phe substitution at the N-terminal side of Tyr 51 and an Ala-to-Asp substitution at the C-terminal side of Tyr 51 (S2-FE) showed improved interaction affinities for the MMP-7 pro-domain. Compared to S2-P, S2-FE was better able to inhibit the SDC2–MMP-7 interaction, the cell surface localization of MMP-7, the gelatin degradation activity of MMP-7, and the cancer activities (cell migration, invasion, and colony-forming activity) of human HCT116 colon cancer cells in vitro. In vivo, S2-FE inhibited the primary tumor growth and lung metastasis of CT26 mouse colon cancer cells in a xenograft mouse model. Together, these data suggest that S2-FE could be useful therapeutic anticancer peptides for colon cancer. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.subject | colon cancer | - |
dc.subject | matrix metalloproteinase-7 | - |
dc.subject | syndecan-2 | - |
dc.subject | therapeutic agent | - |
dc.title | Substituted Syndecan-2-Derived Mimetic Peptides Show Improved Antitumor Activity over the Parent Syndecan-2-Derived Peptide | - |
dc.type | Article | - |
dc.relation.issue | 11 | - |
dc.relation.volume | 23 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | International Journal of Molecular Sciences | - |
dc.identifier.doi | 10.3390/ijms23115888 | - |
dc.identifier.wosid | WOS:000808963400001 | - |
dc.identifier.scopusid | 2-s2.0-85130848267 | - |
dc.author.google | Jang B. | - |
dc.author.google | Kim A. | - |
dc.author.google | Lee Y. | - |
dc.author.google | Hwang J. | - |
dc.author.google | Sung J.-Y. | - |
dc.author.google | Jang E.-J. | - |
dc.author.google | Kim Y.-N. | - |
dc.author.google | Yun J.-H. | - |
dc.author.google | Han J. | - |
dc.author.google | Song J.-J. | - |
dc.author.google | Lee W. | - |
dc.author.google | Oh E.-S. | - |
dc.contributor.scopusid | 오억수(7101967153) | - |
dc.contributor.scopusid | 황지선(7403896831) | - |
dc.contributor.scopusid | 장보희(55242403100) | - |
dc.date.modifydate | 20230201093717 | - |