Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2022-07-13T16:30:03Z | - |
dc.date.available | 2022-07-13T16:30:03Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2161-1653 | * |
dc.identifier.other | OAK-31698 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261480 | - |
dc.description.abstract | Thermogelling behavior of aqueous polymer solutions comes from the delicate balance between hydrophilic and hydrophobic moieties of the polymer. Typically, poly(ethylene glycol) (PEG) has been used as a hydrophilic block in most thermogels reported to date. However, recent papers have suggested the potential immunogenicity of PEG-conjugated compounds. Here, we report that aqueous solutions of dl-polyalanine (DL-PA) with a specific molecular weight can exhibit thermogelling behavior. In particular, DL-PA with a molecular weight (M-n) of 6690 Da, DL-PA67, exhibited sol-to-gel transition at the physiologically important temperature range of 30-40 degrees C. H-1 NMR and FTIR data indicated that the mechanism of thermogelation is related to dehydration and conformational changes of DL-PA67 from random coil to beta-sheet structures. Subcutaneous injection of an aqueous DL-PA67 solution into rats confirmed the gel formation and its histocompatibility with mild tissue irritation. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | DL-Polyalanine as a PEG-Free Thermogel | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 825 | * |
dc.relation.lastpage | 829 | * |
dc.relation.journaltitle | ACS MACRO LETTERS | * |
dc.identifier.doi | 10.1021/acsmacrolett.2c00267 | * |
dc.identifier.wosid | WOS:000815248000001 | * |
dc.identifier.scopusid | 2-s2.0-85132455609 | * |
dc.author.google | Lee, Hyun Jung | * |
dc.author.google | Jeong, Byeongmoon | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |