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자연과학대학
화학·나노과학전공
Journal papers
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Reactivity Differences Enable ROS for Selective Ablation of Bacteria
Title
Reactivity Differences Enable ROS for Selective Ablation of Bacteria
Authors
Wu X.
;
Yang M.
;
Kim J.S.
;
Wang R.
;
Kim G.
;
Ha J.
;
Kim H.
;
Cho Y.
;
Nam K.T.
;
Yoon J.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영
Issue Date
2022
Journal Title
Angewandte Chemie - International Edition
ISSN
1433-7851
Citation
Angewandte Chemie - International Edition vol. 61, no. 17
Keywords
Antibacterial Agents
;
Gram-Positive Bacteria
;
Photodynamic Therapy
;
Reactivity Difference
;
Selective Ablation
Publisher
John Wiley and Sons Inc
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
An effective strategy to engineer selective photodynamic agents to surmount bacterial-infected diseases, especially Gram-positive bacteria remains a great challenge. Herein, we developed two examples of compounds for a proof-of-concept study where reactive differences in reactive oxygen species (ROS) can induce selective ablation of Gram-positive bacteria. Sulfur-replaced phenoxazinium (NBS-N) mainly generates a superoxide anion radical capable of selectively killing Gram-positive bacteria, while selenium-substituted phenoxazinium (NBSe-N) has a higher generation of singlet oxygen that can kill both Gram-positive and Gram-negative bacteria. This difference was further evidenced by bacterial fluorescence imaging and morphological changes. Moreover, NBS-N can also successfully heal the Gram-positive bacteria-infected wounds in mice. We believe that such reactive differences may pave a general way to design selective photodynamic agents for ablating Gram-positive bacteria-infected diseases. © 2022 Wiley-VCH GmbH.
DOI
10.1002/anie.202200808
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